Evidence map›Paper›PMID 41589347›Full record

ArticleCNS neuroscience & therapeutics2026

Impact of Anesthesia With Propofol on Epileptic Discharges Recorded by Stereo-Electroencephalography in Pediatric Epilepsy Surgery.

Chang Liu, Ping Ding, Tong Zhao, Tinghong Liu, Shijie Wu, Yuxiang Yan, Liu Yuan, Liwei Zhang, Shuli Liang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in CNS neuroscience & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chang LiuDepartment of Functional Neurosurgery, National Center for Children's Health of China, Beijing Children's Hospital, Capital Medical University, Beijing, China.ORCID 0000-0001-6619-7019
Ping DingDepartment of Functional Neurosurgery, National Center for Children's Health of China, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Tong ZhaoGnosis Neurodynamics Co. Ltd, Beijing, China.ORCID 0000-0001-9907-3186
Tinghong LiuDepartment of Functional Neurosurgery, National Center for Children's Health of China, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Shijie WuDepartment of Functional Neurosurgery, National Center for Children's Health of China, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Yuxiang YanGnosis Neurodynamics Co. Ltd, Beijing, China.
Liu YuanDepartment of Functional Neurosurgery, National Center for Children's Health of China, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Liwei ZhangDepartment of Functional Neurosurgery, National Center for Children's Health of China, Beijing Children's Hospital, Capital Medical University, Beijing, China.
Shuli LiangDepartment of Functional Neurosurgery, National Center for Children's Health of China, Beijing Children's Hospital, Capital Medical University, Beijing, China.ORCID 0000-0002-7292-745X

Funding

National Natural Science Foundation of China 82301638"Yangfan" Program by the Beijing Municipal Hospital Administration Center YGLX202531
6 · The paper itself

Abstract

objectiveThis study aimed to evaluate the influence of anesthesia with propofol on epileptic discharges recorded by stereo-electroencephalography (SEEG) during pediatric epilepsy surgery.

methodsWe enrolled 30 pediatric patients (aged 2-14 years) undergoing epilepsy surgery between June 2022 and November 2023. SEEG recordings were obtained under different states of consciousness: awake, sleep, and anesthesia. We analyzed the power spectral density (PSD) across frequency bands and quantified the number of interictal spikes and high-frequency oscillations (HFO) including ripples and fast ripples (FRs).

resultsThere was a significant reduction in the number of spikes, particularly within the seizure onset zone (SOZ), while ripples and FRs increased under general anesthesia, but the extent of the increase did not differ between the SOZ and other detected brain regions (NSOZ). Analysis of PSD showed increased energy during anesthesia, particularly in high-frequency bands. Meanwhile, no statistical differences were observed in energy changes between the SOZ and NSOZ when compared to wakefulness or sleep. HFOs emerged as more robust and consistent interictal biomarkers for localizing the SOZ under propofol anesthesia, particularly in the frontal cortex and cingulate cortex, and were not influenced by age.

conclusionsGeneral anesthesia with propofol significantly affects the number and frequency of epileptic discharges, particularly by reducing spikes while increasing HFOs. Notably, HFOs-particularly in the frontal and cingulate cortices-emerged as reliable biomarkers for delineating the SOZ and guiding surgical resections. Furthermore, no significant age-related variability was identified, supporting the applicability of intra-operative electroencephalography in pediatric epilepsy surgery.

Indexed as

Anesthetics, IntravenousElectroencephalographyEpilepsyPropofolAdolescentAnesthesia, GeneralBrainChildChild, PreschoolFemaleHumansMalePediatric AnesthesiaAnesthetics, IntravenousPropofolanesthesiaepilepsy surgeryhigh‐frequency oscillationintra‐operative electroencephalographypower spectral density

Identifiers

PMID41589347
PMCPMC12835890

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.