Evidence map›Paper›PMID 41589331›Full record

ArticleExperimental physiology2026

Lower cerebral blood flow but not cerebrovascular response in elastin haploinsufficient mice.

Abigail E Cullen, Emily H Reeve, Nick R Winder, Grant D Henson, Nayantara Arora, Thomas Leonhardt, Ainsley Hogan, Sahana Krishna Kumaran, Naly Setthavonsack, Victoria Krajbich and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Experimental physiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors.

Abigail E CullenHuman Physiology, University of Oregon, Eugene, Oregon, USA.
Emily H ReeveHuman Physiology, University of Oregon, Eugene, Oregon, USA.
Nick R WinderHuman Physiology, University of Oregon, Eugene, Oregon, USA.
Grant D HensonHuman Physiology, University of Oregon, Eugene, Oregon, USA.
Nayantara AroraHuman Physiology, University of Oregon, Eugene, Oregon, USA.
Thomas LeonhardtHuman Physiology, University of Oregon, Eugene, Oregon, USA.
Ainsley HoganHuman Physiology, University of Oregon, Eugene, Oregon, USA.
Sahana Krishna KumaranHuman Physiology, University of Oregon, Eugene, Oregon, USA.
Naly SetthavonsackPathology and Laboratory Medicine, School of Medicine, Oregon Health and Science University, Portland, Oregon, USA.
Victoria KrajbichPathology and Laboratory Medicine, School of Medicine, Oregon Health and Science University, Portland, Oregon, USA.
Art RiddleDepartment of Pediatrics, Oregon Health and Science University, Portland, Oregon, USA.
Benjamin ZimmermanHelfgott Research Institute, National University of Natural Medicine, Portland, Oregon, USA.
Nabil J AlkayedKnight Cardiovascular Institute, Oregon Health and Science University, Portland, Oregon, USA.
Martin M PikeBiomedical Engineering, Advanced Imaging Research Center, Oregon Health and Science University, Portland, Oregon, USA.
Randall L WoltjerPathology and Laboratory Medicine, School of Medicine, Oregon Health and Science University, Portland, Oregon, USA.
Ashley E WalkerHuman Physiology, University of Oregon, Eugene, Oregon, USA.

Funding

Research Education ComponentP30AG066518 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI KEVIN M DUFF, Lisa C Silbert · 2020 to 2026
$28.6M
Oregon Clinical and Translational Research Institute TL1 ProgramTL1TR002371 · NCATS · OREGON HEALTH & SCIENCE UNIVERSITY · PI ALLISON Deborah FRYER, JESSINA C MCGREGOR · 2017 to 2026
$6.2M
Neuroinflammatory Mechanisms of Vascular Cognitive ImpairmentRF1AG058273 · NIA · OREGON HEALTH & SCIENCE UNIVERSITY · PI ALKAYED, NABIL J · 2017 to 2023
$4.2M
Large artery stiffness and cerebrovascular dysfunction: Implications for cognitive impairment and neuropathologyR01AG064016 · NIA · UNIVERSITY OF OREGON · PI WALKER, ASHLEY ELIZABETH · 2020 to 2024
$2.3M
NCATS NIH HHS TL1 TR002371NIA NIH HHS P30 AG066518NIA NIH HHS R01 AG064016NIA NIH HHS RF1 AG058273NIH HHS R01AG064016NIH HHS TL1TR002371Oregon Alzheimer's Disease Research Center P30AG066518Oregon Partnership for Alzheimer's Research Tax Checkoff
6 · The paper itself

Abstract

Elastin insufficiency is associated with structural differences in the large elastic arteries and cerebral artery dysfunction. However, previous studies have not assessed potential sex differences in cerebrovascular function. We measured cerebral blood flow (CBF) using arterial spin labeling MRI at rest and in response to hypercapnia challenge (cerebrovascular responsiveness, CR) in middle-aged and old elastin haploinsufficient (Eln

Indexed as

Brain volumecerebrovascular reactivityelastin haploinsufficiencyneuroinflammation

Identifiers

PMID41589331
PMCPMC13394619

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.