Evidence map›Paper›PMID 41589327›Full record

ArticleJournal of psychopharmacology (Oxford, England)2026

Drug harms in Canada: A multi-criteria decision analysis.

Jean-François Crépault, Cayley Russell, Mark Asbridge, Matthew Bonn, Michael Chaiton, Karleigh Darnay, Robert Henry, David C Hodgins, Elaine Hyshka, Didier Jutras-Aswad and 13 more

Abstract read
In one paragraph

Article in Journal of psychopharmacology (Oxford, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Jean-François CrépaultCentre for Addiction and Mental Health, Toronto, ON, Canada.ORCID 0000-0003-0448-560X
Cayley RussellCentre for Addiction and Mental Health, Toronto, ON, Canada.ORCID 0000-0001-9634-9554
Mark AsbridgeDepartment of Community Health and Epidemiology, Dalhousie University, Halifax, NS, Canada.
Matthew BonnChangemark Research+Evaluation, Vancouver, BC, Canada.ORCID 0000-0002-6406-0171
Michael ChaitonCentre for Addiction and Mental Health, Toronto, ON, Canada.ORCID 0000-0002-9589-2122
Karleigh DarnayCentre for Addiction and Mental Health, Toronto, ON, Canada.
Robert HenryDepartment of Indigenous Studies, University of Saskatchewan, Saskatoon, SK, Canada.
David C HodginsDepartment of Psychology, University of Calgary, AB, Canada.ORCID 0000-0003-2737-5200
Elaine HyshkaSchool of Public Health, University of Alberta, Edmonton, AB, Canada.
Didier Jutras-AswadCentre hospitalier de l'Université de Montréal, Montréal, QC, Canada.ORCID 0000-0002-8474-508X
Bernard Le FollCentre for Addiction and Mental Health, Toronto, ON, Canada.ORCID 0000-0002-6406-4973
Sean PatenaudeCentre for Addiction and Mental Health, Toronto, ON, Canada.ORCID 0009-0006-7835-4011
Peter SelbyCentre for Addiction and Mental Health, Toronto, ON, Canada.ORCID 0000-0001-5401-2996
Adam SherkCanadian Institute for Substance Use Research, University of Victoria, Victoria, BC, Canada.
Kevin D ShieldCentre for Addiction and Mental Health, Toronto, ON, Canada.
M Eugenia SocíasBritish Columbia Centre on Substance Use, Vancouver, BC, Canada.ORCID 0000-0003-2556-7049
Sherry H StewartDepartment of Community Health and Epidemiology, Dalhousie University, Halifax, NS, Canada.
Maria ZhangCentre for Addiction and Mental Health, Toronto, ON, Canada.
Farihah AliCentre for Addiction and Mental Health, Toronto, ON, Canada.ORCID 0000-0002-2968-3824
Rose CrossinDepartment of Population Health, University of Otago, Christchurch, New Zealand.ORCID 0000-0003-1814-1330
Lawrence PhillipsDrug Science, London, United Kingdom.
David NuttDrug Science, London, United Kingdom.ORCID 0000-0002-1286-1401
Jürgen RehmCentre for Addiction and Mental Health, Toronto, ON, Canada.ORCID 0000-0001-5665-0385

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundMulti-criteria decision analysis (MCDA) has been used to quantify drug harms in the United Kingdom, the European Union, Australia, and New Zealand. This paper presents the result of an MCDA conducted in Canada, with the aim of informing Canadian drug policy and contributing to public understanding of drugs' relative harms.

methodsA panel composed of 20 experts from six provinces determined 16 drugs to evaluate on 16 dimensions of harm (ten representing harm to people who use the drug; six representing harm to others). At a two-day decision conference, the panel scored each drug on a scale of 0-100 for each harm criterion, then weighted the relative importance of each criterion.

resultsThis analysis of drug harms in Canada found that alcohol causes the most harm overall, with a cumulative weighted score of 79. It was followed by tobacco (45), nonprescription opioids (33), cocaine (19), methamphetamine (19), and cannabis (15). The finding that alcohol causes the most harm is consistent with the results of previous MCDA drug harm studies.

conclusionThese harm scores express population-level harm rather than individual-level "harmfulness." They reflect not only a drug's pharmacological risk profile but also the current policy context in Canada. The high score for alcohol underscores a failure to adopt policies to address alcohol-related harms, despite the known health harms and the existence of proven policy measures. More broadly, when developing drug policies, governments should consider the harm-both individual and societal-caused by drugs and by the laws and regulations that govern them.

Indexed as

Decision Support TechniquesSubstance-Related DisordersCanadaHumansIllicit DrugsIllicit Drugsdrug policymulti-criteria decision analysispsychoactive substances

Identifiers

PMID41589327
PMCPMC13222387

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.