Evidence map›Paper›PMID 41589249›Full record

ArticleInternational cancer conference journal2026

A rare case of mastitis involving granulomatosis with polyangiitis after immune checkpoint inhibitor therapy.

Chieko Mishima, Akane Watanabe, Yuichi Motoyama, Takahiro Kodama, Ryu Tokui, Yasufumi Sato, Nanae Masunaga, Masami Tsukabe, Yoshiaki Sota, Tetsuhiro Yoshinami and 2 more

Abstract read
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Article in International cancer conference journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Chieko MishimaDepartment of Breast and Endocrine Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E10 Yamadaoka, Suita, Osaka 565-0871 Japan.ORCID 0009-0009-9610-5758
Akane WatanabeDepartment of Respiratory Medicine and Clinical Immunology, Graduate School of Medicine, The University of Osaka, Osaka, Japan.
Yuichi MotoyamaDepartment of Pathology, Graduate School of Medicine, The University of Osaka, Osaka, Japan.
Takahiro KodamaDepartment of Gastroenterology and Hepatology, Graduate School of Medicine, The University of Osaka, Osaka, Japan.
Ryu TokuiDepartment of Breast and Endocrine Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E10 Yamadaoka, Suita, Osaka 565-0871 Japan.
Yasufumi SatoDepartment of Breast and Endocrine Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E10 Yamadaoka, Suita, Osaka 565-0871 Japan.
Nanae MasunagaDepartment of Breast and Endocrine Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E10 Yamadaoka, Suita, Osaka 565-0871 Japan.
Masami TsukabeDepartment of Breast and Endocrine Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E10 Yamadaoka, Suita, Osaka 565-0871 Japan.
Yoshiaki SotaDepartment of Breast and Endocrine Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E10 Yamadaoka, Suita, Osaka 565-0871 Japan.
Tetsuhiro YoshinamiDepartment of Breast and Endocrine Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E10 Yamadaoka, Suita, Osaka 565-0871 Japan.
Tomonori TaneiDepartment of Breast and Endocrine Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E10 Yamadaoka, Suita, Osaka 565-0871 Japan.
Kenzo ShimazuDepartment of Breast and Endocrine Surgery, Graduate School of Medicine, The University of Osaka, 2-2-E10 Yamadaoka, Suita, Osaka 565-0871 Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Immune-related adverse events (irAE) are a concern during immune checkpoint inhibitor therapy (ICI), and vasculitis is a rheumatic irAE. Granulomatosis with polyangiitis (GPA) is an anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis characterized by necrotizing granulomatosis. GPA in the mammary glands is rare and causes granulomatous mastitis. We describe an older woman with metastatic hepatocellular carcinoma who was receiving ICI therapy. She developed a rapidly growing painful mass in her right breast. Biopsy of the breast revealed necrotizing granulomatous mastitis, which implied an association with autoimmune disease. We detected c-ANCA (proteinase 3)-positivity and a nodule forming a cavity in her right lung; lung biopsy revealed granulomatosis. We diagnosed GPA, possibly arising as an irAE. Prompt initiation of prednisolone therapy led to complete resolution of clinical symptoms within 2 weeks. This case represents the first known report of rare autoimmune mastitis with GPA flared after ICI therapy.

Indexed as

Antineutrophil cytoplasmic antibodyGranulomatosis with polyangiitisGranulomatous mastitisImmune checkpoint inhibitorsImmune-related adverse events

Identifiers

PMID41589249
PMCPMC12831740

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