Evidence map›Paper›PMID 41589135›Full record

ArticleJournal of clinical biochemistry and nutrition2026

Mixed lesions in premalignant colorectal polyps.

Toru Arano, Toshihiro Nishizawa, Hidenobu Watanabe, Mari Mizutani, Teppei Akimoto, Masaya Sano, Hirotoshi Ebinuma, Hidekazu Suzuki, Keisuke Hata, Osamu Toyoshima

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of clinical biochemistry and nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Toru AranoGastroenterology, Toyoshima Endoscopy Clinic, 6-17-5 Seijo, Setagaya-ku, Tokyo 157-0066, Japan.
Toshihiro NishizawaGastroenterology, Toyoshima Endoscopy Clinic, 6-17-5 Seijo, Setagaya-ku, Tokyo 157-0066, Japan.
Hidenobu WatanabeDepartment of Pathology, Pathology and Cytology Laboratory Japan, 1 Ichigaya-Sannai-cho, Shinjuku-ku, Tokyo 162-0846, Japan.
Mari MizutaniGastroenterology, Toyoshima Endoscopy Clinic, 6-17-5 Seijo, Setagaya-ku, Tokyo 157-0066, Japan.
Teppei AkimotoDivision of Research and Development for Minimally Invasive Treatment Cancer Center Keio University School of Medicine, 35 Shinano-machi Shinjuku-ku, Tokyo 160-0016, Japan.
Masaya SanoGastroenterology, Toyoshima Endoscopy Clinic, 6-17-5 Seijo, Setagaya-ku, Tokyo 157-0066, Japan.
Hirotoshi EbinumaDepartment of Gastroenterology and Hepatology, International University of Health and Welfare Narita Hospital, 852 Hatakeda, Narita, Chiba 286-8520, Japan.
Hidekazu SuzukiDivision of Gastroenterology and Hepatology, Department of Internal Medicine, Tokai University School of Medicine, 143 Shimokasuya, Isehara-shi, Kanagawa 259-1193, Japan.
Keisuke HataGastroenterology, Toyoshima Endoscopy Clinic, 6-17-5 Seijo, Setagaya-ku, Tokyo 157-0066, Japan.
Osamu ToyoshimaGastroenterology, Toyoshima Endoscopy Clinic, 6-17-5 Seijo, Setagaya-ku, Tokyo 157-0066, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Colonoscopists occasionally encounter mixed lesions with overlapping histological features. The frequency and combinations of such mixed colorectal polyps remain poorly understood. We comprehensively analyzed the frequencies and combinations of histologically mixed premalignant colorectal polyps. This study had a retrospective, single-center, cross-sectional design. Patients who underwent colonoscopy at the Toyoshima Endoscopy Clinic between March 2022 and July 2023 were eligible. We excised lesions diagnosed as conventional adenomas or clinically significant serrated polyps. Among these polyps, we focused on mixed lesions and analyzed their frequency and combinations. Among 9,682 resected colorectal lesions, 61 (0.63%) were classified as mixed lesions. The most common combination was microvesicular hyperplastic polyp (MVHP) + goblet cell-rich hyperplastic polyp (GCHP) (41.0%), followed by sessile serrated lesion (SSL) + traditional serrated adenoma (TSA) (21.3%), MVHP + conventional adenoma (9.8%), and TSA + conventional adenoma (9.8%). The mixed rates for MVHPs, GCHPs, SSLs, TSAs, and conventional adenomas were 2.3%, 3.7%, 2.9%, 53.5%, and 0.28%, respectively. Mixed MVHP + GCHP lesions were significantly larger than pure GCHPs (5.3 ‍mm vs 4.0 ‍mm,

Indexed as

colongoblet cellhyperplastic polypmicrovesicularmixed lesion

Identifiers

PMID41589135
PMCPMC12832143

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.