Serotype Prevalence of Group B

Background: Group B Materials and Methods: A systematic search was conducted in MEDLINE (via PubMed), Embase, Web of Science, and the Iranian Databases (SID and Magiran) for studies published between January 2000 and March 2023. Studies were included if they used standardized methods for GBS detection, including recto-vaginal specimen collection and identification [selective media and molecular detection of GBS-specific gene ( Results: Of 330 articles identified, 14 studies met the inclusion criteria. The meta-analyses showed that 93.2% (95% CI: 90-95.5) of GBS isolates had identifiable serotypes. The predominant serotype was serotype III [39.6% (95% CI: 31.6-48.2)], followed by serotypes II [16.8% (95% CI: 13.8-20.4)], V [14.1% (95% CI: 11.2-17.6)], VI [12.4 (95% CI: 8.2-18.5)], Ia [11.7% (95 CI: 7.8-17.2)] and Ib [11.2 (95% CI: 6.9-17.6)]. Conclusion: Serotype III is the most common GBS serotype among pregnant women in Iran, followed by serotypes II, V, VI, Ia, and Ib. These findings suggest that a pentavalent vaccine targeting these serotypes could be beneficial for preventing GBS-related complications in Iranian pregnant women. However, further research is needed to evaluate the efficacy and implementation of such a vaccine.