ArticleMagnetic resonance in medicine2026
Modeling the Intermediate Flow Regime in Flow-Compensated Intravoxel Incoherent Motion MRI.
Article in Magnetic resonance in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Evaluation of the diffusion time dependence of the IVIM effect based on realistic capillary flow simulations in mouse brain.Magma (New York, N.Y.) · 2026Article
- Validation of Intravoxel Incoherent Motion MRI Using Perfused Explanted Human Livers.Magnetic resonance in medicine · 2026Article
- Reproducibility of intravoxel incoherent motion quantification in the liver across field strengths and gradient hardware.Magnetic resonance in medicine · 2024Article
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Authors and funding
6 authors.
Funding
Abstract
purposeThe intravoxel incoherent motion (IVIM) model is commonly used to separate the effects of motion related to diffusion and blood microcirculation (perfusion) on the MR signal. Depending on the encoding time (T), it is possible to probe the different temporal regimes of blood motion, which resemble a ballistic flow at short T and a pseudo-diffusion at long T. The purpose of this work was to derive an encoding-time-dependent analytical model for flow-compensated IVIM and to estimate the corresponding microvascular IVIM parameters in healthy brain. THEORY AND
methodsAn encoding-time-dependent analytical IVIM model was derived for flow-compensated/non-flow-compensated (FC/NC) double diffusion encoding (DDE) from the Langevin equation and validated using simulations. Eleven healthy participants were scanned to estimate microvascular IVIM parameters (blood velocity ν and blood correlation time τ) in healthy brain using the proposed model, with T = 50-100 ms.
resultsThe IVIM parameters were estimated to be τ = 123.1 ± 50 ms, ν = 1.51 ± 0.76 mm/s, perfusion fraction f = 4.75 ± 1.94%, and tissue diffusion coefficient D = 0.91 ± 0.32 μm
conclusionAn encoding-time-dependent analytical IVIM model is presented for FC/NC DDE. In vivo results and simulations indicate that IVIM experiments with encoding times typical for clinical MRI scanners probe an intermediate to ballistic blood flow regime in the brain.
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