Evidence map›Paper›PMID 41588674›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

XIAP Stabilizes DDRGK1 to Promote ER-Phagy and Protects Against Noise-Induced Hearing Loss.

Lin Yan, Yuhua Zhang, Jiawei Du, Yongjun Zhu, Wei Cao, Yongjie Wei, Han Wu, Shiyu Qiu, Shiyi Pan, Lian Chen and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Lin YanDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Yuhua ZhangDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Jiawei DuDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Yongjun ZhuDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Wei CaoDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Yongjie WeiDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Han WuDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Shiyu QiuDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Shiyi PanDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Lian ChenDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Pingping LiangSchool of Life Sciences, Anhui Medical University, Hefei, China.
Renjie ChaiState Key Laboratory of Digital Medical Engineering, Department of Otolaryngology Head and Neck Surgery, Zhongda Hospital, School of Life Sciences and Technology, School of Medicine, Advanced Institute For Life and Health, Jiangsu Province High-Tech Key Laboratory for Bio-Medical Research, Southeast University, Nanjing, China.ORCID https://orcid.org/0000-0002-3885-543X
Jianming YangDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.
Qiaojun FangDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Anhui Medical University, Hefei, China.ORCID https://orcid.org/0009-0001-8447-1779

Funding

2022 Open Project Fund of Guangdong Academy of Medical Sciences YKY-KF202201Anhui Natural Science Foundation 2208085MH223Anhui Province Scientific Research Preparation Plan Project 2022AH050655Anhui Province Scientific Research Preparation Plan Project 2022AH050685Anhui Provincial Clinical Medicine Research Translation Special Project 202527c10020083China Postdoctoral Science Foundation 2023M740025China Postdoctoral Science Foundation 2024M750022Doctoral Start-up Foundation of Anhui Medical University 0801029201Jiangsu Provincial Scientific Research Center of Applied Mathematics BK20233002National Key R&D Program of China 2020YFA0112503National Key R&D Program of China 2021YFA1101300National Key R&D Program of China 2021YFA1101800National Natural Science Foundation of China 82030029National Natural Science Foundation of China 82071055National Natural Science Foundation of China 82271178National Natural Science Foundation of China 82330033National Natural Science Foundation of China 82471178National Natural Science Foundation of China 92149304National Science Foundation for Young Scientists of China 82000986National Science Foundation for Young Scientists of China 82102851National Science Foundation for Young Scientists of China 82201297National Science Foundation for Young Scientists of China 82301315National Science Foundation for Young Scientists of China 82401367Natural Science Foundation of Jiangsu Province BK20232007Research Fund of Anhui Institute of Translational Medicine 2023zhyx-C12Science and Technology Department of Sichuan Province 2021YFS0371Shenzhen Science and Technology Program JCYJ20190814093401920Shenzhen Science and Technology Program JCYJ20210324125608022STI2030-Major Projects 2022ZD0207600
6 · The paper itself

Abstract

Noise-induced hearing loss (NIHL) is a common cause of acquired sensorineural hearing loss. Excessive endoplasmic reticulum (ER) stress-induced apoptosis of cochlear hair cells contributes to NIHL. ER autophagy (ER-phagy) is a critical pathway for maintaining ER homeostasis and cell survival. DDRGK1 (DDRGK domain containing 1) is a crucial receptor in ER-phagy, essential for the removal of injured ER components. This work investigates the involvement of DDRGK1-mediated ER-phagy in NIHL, which has remained unclear. ER-phagy flux is inhibited in HEI-OC1 cells treated with hydrogen peroxide. Noise exposure reduces XIAP (X-linked inhibitor of apoptosis protein) and DDRGK1 protein levels in these cells. Moreover, XIAP binds to DDRGK1, increasing the stability of DDRGK1 and activating ER-phagy. Notably, in noise-exposed CBA/CaJ mice, gastrodin, a traditional Chinese medicine ingredient, reduces noise-induced loss of cochlear hair cells, ribbon synaptic damage, and hearing loss by promoting XIAP expression, thereby increasing DDRGK1 protein levels and activating ER-phagy. These findings highlight XIAP-DDRGK1-mediated ER-phagy as a novel therapeutic target for NIHL treatment.

Indexed as

AutophagyEndoplasmic ReticulumEndoplasmic Reticulum StressHearing Loss, Noise-InducedX-Linked Inhibitor of Apoptosis ProteinAnimalsApoptosisDisease Models, AnimalHair Cells, AuditoryInhibitor of Apoptosis ProteinsMiceBirc4 protein, mouseInhibitor of Apoptosis ProteinsX-Linked Inhibitor of Apoptosis ProteinDDRGK1ER‐phagyhair cellsnoise‐induced hearing lossXIAP

Identifiers

PMID41588674
PMCPMC13042907

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.