ReviewCurrent drug delivery2026
Utilizing Extracellular Vesicles for Delivering Therapies in Neurodegenerative Disorders.
Review in Current drug delivery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neurodegenerative diseases (NDs) are characterized by slow progression and late detection, seriously compromising the efficiency of treatments. The presence of the blood-brain barrier (BBB) significantly impairs conventional therapies. More recently, extracellular vesicles (EVs) have emerged as promising drug delivery systems for brain-targeted therapies due to their ability to cross the BBB and their combination of low immunogenicity, high biocompatibility, and delivery efficiency. EVs play a vital role in intercellular communication, transporting nucleic acids, lipids, and proteins between cells, which are crucial for modulating cellular functions, immune responses, and neuroprotection. They have also demonstrated considerable therapeutic potential by mitigating neuroinflammation, reducing neuronal damage, and alleviating cognitive deficits in preclinical models of NDs. This review discusses various applications of EVs in the treatment of NDs, challenges they present as a delivery vehicle, and future research directions and regulatory considerations in advancing EV-based therapies for neurodegenerative disorders.
Indexed as
Identifiers
41588592What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.