ReviewCurrent protein & peptide science2026
Research Progress on the Intervention of Traditional Chinese Medicine Monomers on Signaling Pathways Related to Sarcopenia and Osteoporosis.
Review in Current protein & peptide science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Nutrition and Metabolism in Musculoskeletal Diseases.Current protein & peptide science · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
Sarcopenia and osteoporosis are conditions characterized by the synergistic effects of sarcopenia and osteoporosis, leading to the loss of muscle mass, muscle strength, bone density, and bone quality. This condition is marked by a high disability rate, limited diagnostic and therapeutic options, and significant clinical harm. The pathogenesis of sarcopenia and osteoporosis involves diminished differentiation of osteoblasts and myoblasts, as well as enhanced proliferation of osteoclasts. Signaling pathways such as Wnt/β-catenin, mitogen-activated protein kinase (MAPK), phosphatidylinositol 3-kinase/protein kinase B (PI3K/Akt), and nuclear factor-κB (NF-κB) play crucial roles in promoting the differentiation of osteoblasts and myoblasts while inhibiting osteoclast differentiation, thereby contributing to the treatment of sarcopenia and osteoporosis. Traditional Chinese medicine (TCM) has demonstrated significant efficacy in addressing "muscle atrophy" and "bone depletion." Both single herbs and compound formulas can achieve therapeutic effects on sarcopenia and osteoporosis by modulating the expression of these signaling pathways. By summarizing the current research on these signaling pathways and TCM interventions, we aim to provide new insights for the clinical prevention and treatment of sarcopenia and osteoporosis using TCM and offer a foundation for further in-depth studies.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.