Evidence map›Paper›PMID 41588579›Full record

ArticlePsyCh journal2026

Cognitive Profiles in Adolescents and Young Adults With Co-Occurring Autism and First-Episode Psychosis: A Preliminary Neuropsychological Investigation.

Domily T Y Lau, Melody M Y Chan, Flora Y M Mo, Se-Fong Hung, Kelly Y C Lai, Patrick W L Leung, Caroline K S Shea

Abstract read
In one paragraph

Article in PsyCh journal, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Domily T Y LauAlice Ho Miu Ling Nethersole Hospital, Hospital Authority, Hong Kong, Hong Kong Special Administrative Region, China.
Melody M Y ChanQueensland Brain Institute, The University of Queensland, St Lucia, Queensland, Australia.ORCID https://orcid.org/0000-0001-9493-0134
Flora Y M MoAlice Ho Miu Ling Nethersole Hospital, Hospital Authority, Hong Kong, Hong Kong Special Administrative Region, China.
Se-Fong HungDepartment of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong Special Administrative Region, China.
Kelly Y C LaiDepartment of Psychiatry, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, Hong Kong Special Administrative Region, China.
Patrick W L LeungDepartment of Psychology, The Chinese University of Hong Kong, Hong Kong, Hong Kong Special Administrative Region, China.ORCID https://orcid.org/0000-0002-0415-0124
Caroline K S SheaAlice Ho Miu Ling Nethersole Hospital, Hospital Authority, Hong Kong, Hong Kong Special Administrative Region, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autism spectrum disorder (ASD) and psychosis are traditionally considered distinct psychiatric conditions with divergent developmental trajectories, yet emerging evidence suggests they may share overlapping neurodevelopmental characteristics. This study examined whether the cognitive profile associated with co-occurring autism and first-episode psychosis (FEP) reflects additive or interactive influences of the two conditions. Neuropsychological profiles were compared across four age-, sex-, intelligence quotient-, and education level-matched groups of adolescents and young adults (n = 45; aged 13-21): individuals with co-occurring ASD and FEP (FEP-ASD), FEP without ASD (FEP-O), ASD without FEP, and non-autistic controls. The FEP-ASD group exhibited an uneven cognitive profile characterised by relative strengths in visuospatial processing and recognition memory, alongside marked impairments in information processing speed, attentional control, and working memory. This pattern resembled the ASD profile but at a lower overall performance level, consistent with the additive impact of psychosis on ASD-related cognitive characteristics. FEP-ASD participants outperformed FEP-O in recognition memory, a domain usually preserved in ASD but impaired in psychosis. These preliminary findings suggest that co-occurring ASD and psychosis may produce a cognitive profile shaped by influences from both conditions. Larger longitudinal and multimodal studies are needed to clarify the underlying mechanisms.

Indexed as

Autism Spectrum DisorderAutistic DisorderCognitionPsychotic DisordersAdolescentAttentionFemaleHumansMaleMemory, Short-TermNeuropsychological TestsProcessing SpeedYoung Adultautismcognitionfirst‐episode psychosisneuropsychologypsychiatric comorbidity

Identifiers

PMID41588579
PMCPMC12834706

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.