Evidence map›Paper›PMID 41588544›Full record

ArticleAntimicrobial resistance and infection control2026

Could the load of carbapenemase genes in hospital wastewater be a proxy for emerging resistance to carbapenems in humans?

Camille Favier, Mylène Toubiana, Isabelle Zorgniotti, Olivier Courot, Franz Durandet, Patricia Licznar-Fajardo, Estelle Jumas-Bilak

Abstract read
In one paragraph

Article in Antimicrobial resistance and infection control, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Camille FavierHSM, Univ Montpellier, CNRS, IRD, Montpellier, France.
Mylène ToubianaHSM, Univ Montpellier, CNRS, IRD, Montpellier, France.
Isabelle ZorgniottiHSM, Univ Montpellier, CNRS, IRD, Montpellier, France.
Olivier CourotIAGE, Montpellier, France.
Franz DurandetIAGE, Montpellier, France.
Patricia Licznar-FajardoHSM, Univ Montpellier, CNRS, IRD, Montpellier, France.
Estelle Jumas-BilakHSM, Univ Montpellier, CNRS, IRD, Montpellier, France. estelle.bilak@umontpellier.fr.

Funding

PHySE-HSM project (university of Montpellier) UMR5151
6 · The paper itself

Abstract

backgroundAntimicrobial resistance (AMR) poses a growing threat to global public health and is a key concern for infection control teams in hospitals. However, AMR surveillance is time-consuming and limited in most countries, resulting in incomplete findings. In high-income countries, infection control teams ensure the contact tracing of every patient carrying an emerging extensively drug-resistant bacterium which is very time-consuming. Wastewater surveillance (WWS) has been proposed as an alternative approach for the surveillance of infectious diseases. This study aims to test the feasibility of AMR WWS under real-world conditions in hospital. It investigates the dynamics of endemic (bla

methodsThe sampling programmes were adapted according to the sampling sites and patient flow for each hospital building. Genes were quantified in the effluent using qPCR and dPCR. Cultivable carbapenemase-producing Gram-negative bacteria were characterised using MALDI-TOF MS and PCR.

resultsThe feasibility of AMR monitoring in wastewater in real hospital conditions was demonstrated by dPCR and qPCR, which produced correlated results. The presence of peaks and the low load of the vanA and bla

conclusionThis study shows the WWS feasibility in real hospital conditions and preliminary findings regarding patient populations but identified obstacles that need to be overcome prior to use WWS for routine surveillance in an infection control hospital context.

Indexed as

Anti-Bacterial AgentsBacterial Proteinsbeta-LactamasesCarbapenemsGram-Negative BacteriaWastewaterHospitalsHumansMicrobial Sensitivity TestsAnti-Bacterial AgentsBacterial Proteinsbeta-LactamasescarbapenemaseCarbapenemsWastewaterAntimicrobial resistanceCarbapenemasedPCRExtensively drug-resistantGram negative bacilliHealthcare-associated infectionqPCRWastewater-based epidemiology

Identifiers

PMID41588544
PMCPMC12914965

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.