SynthesisBMC public health2026
Association between adverse childhood experiences and asthma: a meta-analysis.
Synthesis in BMC public health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Developmental co-calibration and therapeutic recalibration: a neurobiopsychosocial model of regulatory path dependence in psychosomatic care.Frontiers in psychiatry · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThe study explored whether there is an association between adverse childhood experiences (ACEs) and asthma through meta-analysis.
methodsPubMed, Embase, Cochrane Library, and Web of Science were systematically searched up to May 20, 2024. Observational studies reporting associations between adverse childhood experiences (ACEs) and asthma were included. Two reviewers independently screened studies, extracted data, and assessed study quality. Odds ratios (ORs) with 95% confidence intervals (CIs) were pooled using a random-effects model in Stata 15.0. Heterogeneity was evaluated using the I² statistic, publication bias was assessed with Egger’s test and funnel plots, and study quality was evaluated using established assessment tools.
resultSixteen articles (n = 1,291,133) were included. Experiencing ≥ 1 ACE was associated with an increased risk of asthma [adjusted OR = 1.18, 95% CI (1.12–1.24); I²=86.7%, P < 0.001]. Exposure to 2–3 ACEs was associated with asthma [adjusted OR = 1.55, 95% CI (1.45–1.66); I²=38.2%, P = 0.138], and ≥ 4 ACEs showed the highest risk [adjusted OR = 1.98, 95% CI (1.72–2.27); I²=63.3%, P = 0.012]. Sensitivity analyses using the leave-one-out method indicated that the pooled estimates were robust and stable.
conclusionThe current study found a positive relationship between ACEs and asthma, and as the number of ACEs experienced increases, the likelihood of asthma also rises. These findings underscore the importance of early identification and psychosocial support for children exposed to adversity, which may help reduce the long-term risk of asthma and improve overall respiratory health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.