Evidence map›Paper›PMID 41588268›Full record

ArticleMolecular neurobiology2026

Mechanistic Investigation of TSPO-Mediated Dysregulation of Mitochondrial Copper Homeostasis in Microglia and its Role in Perioperative Neurocognitive Disorders.

Youli Fu, Jiahe Lian, Yinglong Liu, Yongxin Liu, Zihan Xu, Haoran Fan, Yongliang Zhu, Yingxia Liang, Lina Sun, Rui Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Youli Fu *Laboratory of Anesthesia and Critical Care Medicine in Colleges and Universities of Shandong Province, School of Anesthesiology, Shandong Second Medical University, Weifang, 261053, China.
Jiahe Lian *Laboratory of Anesthesia and Critical Care Medicine in Colleges and Universities of Shandong Province, School of Anesthesiology, Shandong Second Medical University, Weifang, 261053, China.
Yinglong LiuLaboratory of Anesthesia and Critical Care Medicine in Colleges and Universities of Shandong Province, School of Anesthesiology, Shandong Second Medical University, Weifang, 261053, China.
Yongxin LiuLaboratory of Anesthesia and Critical Care Medicine in Colleges and Universities of Shandong Province, School of Anesthesiology, Shandong Second Medical University, Weifang, 261053, China.
Zihan XuLaboratory of Anesthesia and Critical Care Medicine in Colleges and Universities of Shandong Province, School of Anesthesiology, Shandong Second Medical University, Weifang, 261053, China.
Haoran FanLaboratory of Anesthesia and Critical Care Medicine in Colleges and Universities of Shandong Province, School of Anesthesiology, Shandong Second Medical University, Weifang, 261053, China.
Yongliang ZhuLaboratory of Anesthesia and Critical Care Medicine in Colleges and Universities of Shandong Province, School of Anesthesiology, Shandong Second Medical University, Weifang, 261053, China.
Yingxia LiangLaboratory of Anesthesia and Critical Care Medicine in Colleges and Universities of Shandong Province, School of Anesthesiology, Shandong Second Medical University, Weifang, 261053, China.
Lina SunLaboratory of Anesthesia and Critical Care Medicine in Colleges and Universities of Shandong Province, School of Anesthesiology, Shandong Second Medical University, Weifang, 261053, China.
Rui ZhangLaboratory of Anesthesia and Critical Care Medicine in Colleges and Universities of Shandong Province, School of Anesthesiology, Shandong Second Medical University, Weifang, 261053, China. zhangrui@sdsmu.edu.cn.ORCID http://orcid.org/0009-0007-3113-4238

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Perioperative neurocognitive disorders (PND) are common complications in elderly surgical patients; their mechanisms remain unclear and no effective therapeutic targets exist. This study aims to determine whether copper dyshomeostasis contributes to PND via 18 kDa translocator protein (TSPO)-mediated pathways and to evaluate the therapeutic potential of a TSPO inhibitor. An aged-mouse model of PND was established by right carotid exposure, and BV-2 microglia were stimulated with lipopolysaccharide (LPS) to mimic neuroinflammation. Copper ions, TSPO expression, and mitochondrial function were assessed in the hippocampus, serum, and cultured cells. Postoperative mice exhibited elevated copper levels in both the hippocampus and serum, accompanied by a significant increase in hippocampal TSPO expression. In vitro, LPS-induced TSPO over-expression in BV-2 cells led to copper accumulation and mitochondrial dysfunction, both of which were reversed by the TSPO inhibitor PK11195. TSPO-mediated disruption of copper homeostasis is a critical mechanism in PND, and targeting TSPO offers a novel strategy for PND prevention and treatment.

Indexed as

CopperHomeostasisMicrogliaMitochondriaNeurocognitive DisordersReceptors, GABAAnimalsCell LineHippocampusIsoquinolinesLipopolysaccharidesMaleMiceMice, Inbred C57BLBzrp protein, mouseCopperIsoquinolinesLipopolysaccharidesPK 11195Receptors, GABACopper homeostasis disorderFerredoxin 1MicrogliaMitochondrial dysfunctionPNDTSPO

Identifiers

PMID41588268
PMCPMC12835046

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.