ArticleDermatology and therapy2026
Immune-Modulatory Effects of Bioactive Collagen Peptides Improve Skin Health in Middle-Aged Women.
Article in Dermatology and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06971029 (Effects Of Supplementation With New Technology for Obtaining Low Molecular Weight Hydrolyzed Collagen Vs. Verisol Collagen on Expression Lines, Skin Quality in the Orbicularis Oculi Region, And Serum Levels of Klotho, VEGF, and TGF-Beta), which is not on this map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects Of Supplementation With New Technology for Obtaining Low Molecular Weight Hydrolyzed Collagen Vs. Verisol Collagen on Expression Lines, Skin Quality in the Orbicularis Oculi Region, And Serum Levels of Klotho, VEGF, and TGF-Beta
Who cites it
1 citing paper in PubMed.
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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors.
Funding
Abstract
introductionCollagen peptides are widely used to support skin health, but the immunological mechanisms mediating such effects remain unclear. So, this study investigated the effects of bioactive collagen peptide (BCP) supplementation on facial wrinkles, skin biophysical properties, and systemic levels of transforming growth factor-beta (TGF-β) and Klotho in sedentary middle-aged women.
methodsThis randomized controlled trial included 119 healthy, sedentary women, aged 35-55 years who were randomly assigned to control, Col 2.5 g, or Col 10 g groups. Daily oral supplementation for 12 weeks consisted of either 2.5 g/day or 10 g/day of BCP (Peptpure
resultsSupplementation with 10 g/day of BCP significantly reduced the number (p < 0.0002) and length (p < 0.0424) of wrinkles. Both collagen groups improved skin elasticity (p < 0.0321 for 2.5 g; p < 0.0065 for 10 g) and hydration (p < 0.0471 for 2.5 g; p < 0.0037 for 10 g). Plasma TGF-β levels were significantly elevated in the 2.5 g group (p < 0.0026) and 10 g group (p < 0.0001) compared with controls, as well as Klotho levels for both collagen groups (p < 0.0016 and p < 0.0001, respectively).
conclusionsA 12-week course of Peptpure
trial registrationClinicalTrials.gov identifier: NCT06971029.
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