Evidence map›Paper›PMID 41588257›Full record

ArticleArchives of toxicology2026

Identification of functional genetic components modulating toxicity response to PFOS using genome-wide CRISPR screens in HepG2/C3A cells.

Chanhee Kim, Abderrahmane Tagmount, Zhaohan Zhu, Frances Wilson, Danmeng Li, David A Ostrov, William Brad Barbazuk, Rhonda Bacher, Chris D Vulpe

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Archives of toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Chanhee KimDepartment of Physiological Sciences, Center for Human and Environmental Toxicology, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA. ch.kim@ufl.edu.ORCID 0000-0001-5706-9701
Abderrahmane TagmountDepartment of Physiological Sciences, Center for Human and Environmental Toxicology, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.
Zhaohan ZhuDepartment of Biostatistics, University of Florida, Gainesville, FL, USA.
Frances WilsonDepartment of Physiological Sciences, Center for Human and Environmental Toxicology, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.
Danmeng LiInfectious Diseases and Immunology Department, University of Florida, Gainesville, FL, USA.
David A OstrovDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville, FL, USA.
William Brad BarbazukDepartment of Biology, University of Florida, Gainesville, FL, USA.
Rhonda BacherDepartment of Biostatistics, University of Florida, Gainesville, FL, USA.
Chris D VulpeDepartment of Physiological Sciences, Center for Human and Environmental Toxicology, College of Veterinary Medicine, University of Florida, Gainesville, FL, USA.

Funding

Supplement: CRISPR screens of population relevant genes governing toxicant resilienceR01ES033625 · NIEHS · UNIVERSITY OF FLORIDA · PI CHRISTOPHER D VULPE · 2022 to 2026
$4.1M
Resolving single-cell analysis challenges via data-driven decision frameworks and novel statistical methodsR35GM146895 · NIGMS · UNIVERSITY OF FLORIDA · PI Rhonda Bacher · 2022 to 2026
$1.9M
NIEHS NIH HHS R01 ES033625NIEHS NIH HHS R01ES033625NIGMS NIH HHS R35 GM146895
6 · The paper itself

Abstract

Perfluorooctane sulfonate (PFOS) poses significant health and environmental risks due to its persistence and widespread use and has been linked to various adverse outcomes, such as liver toxicity. Although the molecular responses and toxicity effects of PFOS exposure have been extensively studied, considerable uncertainty remains regarding the causal mechanisms leading to PFOS-associated adverse effects. To help bridge this gap, we conducted CRISPR screens in HepG2/C3A human liver cells exposed to IC

Indexed as

Alkanesulfonic AcidsEnvironmental PollutantsFluorocarbonsCell SurvivalClustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Cas SystemsHep G2 CellsHumansMolecular Docking SimulationAlkanesulfonic AcidsEnvironmental PollutantsFluorocarbonsperfluorooctane sulfonic acidAdverse outcomeCellular toxicityCRISPR screenCross-speciesFunctional toxicogenomicsPFOS

Identifiers

PMID41588257
PMCPMC13043545

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.