Evidence map›Paper›PMID 41588233›Full record

ArticleNature genetics2026

Reply to: a quantitative trait locus for reduced microglial APOE expression associates with reduced cerebral amyloid angiopathy.

Lincoln M P Shade, Qi Qiao, Yuriko Katsumata, Shubhabrata Mukherjee, Jai G Broome, Lance A Johnson, Mark T W Ebbert, Peter T Nelson, David W Fardo

Abstract readLetter
In one paragraph

Article in Nature genetics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Lincoln M P ShadeDepartment of Biostatistics, University of Kentucky College of Public Health, Lexington, KY, USA.ORCID http://orcid.org/0000-0001-6093-4823
Qi QiaoDepartment of Biostatistics, University of Kentucky College of Public Health, Lexington, KY, USA.ORCID http://orcid.org/0000-0003-1240-0506
Yuriko KatsumataDepartment of Biostatistics, University of Kentucky College of Public Health, Lexington, KY, USA.ORCID http://orcid.org/0000-0002-0188-8094
Shubhabrata MukherjeeDepartment of Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-2522-2884
Jai G BroomeDivision of General Internal Medicine, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0001-7638-0749
Lance A JohnsonSanders-Brown Center on Aging and Alzheimer's Disease Research Center, University of Kentucky, Lexington, KY, USA.
Mark T W EbbertSanders-Brown Center on Aging and Alzheimer's Disease Research Center, University of Kentucky, Lexington, KY, USA.ORCID http://orcid.org/0000-0001-9158-4440
Peter T NelsonSanders-Brown Center on Aging and Alzheimer's Disease Research Center, University of Kentucky, Lexington, KY, USA.
David W FardoDepartment of Biostatistics, University of Kentucky College of Public Health, Lexington, KY, USA. david.fardo@uky.edu.ORCID http://orcid.org/0000-0002-7207-4696

Funding

Topographic, cell type and molecular pathway characterization ofAlzheimer's disease using single cell transcriptomics and epigenomicsU19AG060909 · NIA · ALLEN INSTITUTE · PI Ed Lein · 2020 to 2026
$83.6M
Translational pharmacoepidemiology: neuroprotection and neurotoxicity of antihypertensives and strong anticholinergicsU19AG066567 · NIA · KAISER FOUNDATION RESEARCH INSTITUTE · PI CHRISTOPHER DIRK KEENE · 2021 to 2026
$80.4M
Alzheimer's Disease Genetics ConsortiumU01AG032984 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID · 2009 to 2024
$60.4M
THERAPEUTIC EFFECTS OF INTRA-NASAL INSULIN DETEMIRP50AG005136 · NIA · UNIVERSITY OF WASHINGTON · PI GRABOWSKI, THOMAS J. · 1985 to 2019
$57.2M
SUPPLEMENT TO RUSH ALZHEIMERS DISEASE CENTER COREP30AG010161 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI ARFANAKIS, KONSTANTINOS · 1991 to 2020
$49.1M
EPIDEMIOLOGY OF NEURAL RESERVE AND NEUROBIOLOGY IN AGINGR01AG017917 · NIA · RUSH UNIVERSITY MEDICAL CENTER · PI BENNETT, DAVID ALAN · 2001 to 2023
$43.3M
Furthering scientific understanding of mechanisms underlying resilience to the effects of AD pathology by incorporating state of the art quantification of gliosis, inflammation, & synaptic toxicityU01AG006781 · NIA · UNIVERSITY OF WASHINGTON · PI CRANE, PAUL K, LARSON, ERIC B · 1986 to 2020
$39.3M
Whole Genome Sequencing in Ethnically Diverse Cohorts for the ADSP Follow-Up Study (FUS)U01AG057659 · NIA · UNIVERSITY OF MIAMI SCHOOL OF MEDICINE · PI MAYEUX, RICHARD P, PERICAK-VANCE, MARGARET A. · 2017 to 2021
$34.4M
Genome Center for Alzheimer's Disease (GCAD)U54AG052427 · NIA · UNIVERSITY OF PENNSYLVANIA · PI SCHELLENBERG, GERARD DAVID, WANG, LI-SAN · 2016 to 2025
$32.8M
University of Washington Alzheimer's Disease Research CenterP30AG066509 · NIA · UNIVERSITY OF WASHINGTON · PI Thomas J. Grabowski · 2020 to 2026
$29.0M
Strategies for Targeting Astrocyte Reactivity in Alzheimer's Disease and Related DementiasP01AG078116 · NIA · UNIVERSITY OF KENTUCKY · PI PETER T. NELSON · 2022 to 2026
$25.0M
University of Kentucky Alzheimer's Disease Research CenterP30AG072946 · NIA · UNIVERSITY OF KENTUCKY · PI LINDA J VAN ELDIK · 2021 to 2026
$23.5M
Alzheimer's Association 2019-AARG-644082Alzheimer's Association ABA-25-1376140, ABA-22-972169-Invite, ABA-22-972169BrightFocus Foundation (BrightFocus) A2020161SNIA NIH HHS K25 AG055620NIA NIH HHS P01 AG078116NIA NIH HHS P30 AG010161NIA NIH HHS P30 AG066509NIA NIH HHS P30 AG072946NIA NIH HHS P50 AG005136NIA NIH HHS R01 AG015819NIA NIH HHS R01 AG017917NIA NIH HHS R01 AG030146NIA NIH HHS R01 AG036042NIA NIH HHS R01 AG068331NIA NIH HHS R01 AG080589NIA NIH HHS R01 AG081421NIA NIH HHS R01 AG082730NIA NIH HHS RF1 AG057473NIA NIH HHS RF1 AG082339NIA NIH HHS U01 AG006781NIA NIH HHS U01 AG032984NIA NIH HHS U01 AG046152NIA NIH HHS U01 AG057659NIA NIH HHS U01 AG061356NIA NIH HHS U19 AG060909NIA NIH HHS U19 AG066567NIA NIH HHS U54 AG052427NIGMS NIH HHS P20 GM148326NIGMS NIH HHS R35 GM138636NINDS NIH HHS F30 NS124136U.S. Department of Health & Human Services | NIH | Center for Scientific Review (NIH Center for Scientific Review) F30NS124136U.S. Department of Health & Human Services | NIH | Center for Scientific Review (NIH Center for Scientific Review) P30AG072946U.S. Department of Health & Human Services | NIH | Center for Scientific Review (NIH Center for Scientific Review) R01AG082730U.S. Department of Health & Human Services | NIH | Center for Scientific Review (NIH Center for Scientific Review) RF1AG082339
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID41588233
PMCPMC13068160

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.