Deciphering the causal nexus of mitochondrial biology with breast cancer.

Dongsong Liu, Hongfang Xu, Yan Yan, Bingnan Wang, Wangjun Yan

Abstract read

In one paragraph

Article in Discover oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Dongsong Liu *Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, 200032, Shanghai, China.

Hongfang Xu *Department of Rehabilitation, Wuxi No 2 People's Hospital, 214002, Wuxi, China.

Yan Yan *Department of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, 200032, Shanghai, China.

Bingnan WangDepartment of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, 200032, Shanghai, China.

Wangjun YanDepartment of Musculoskeletal Oncology, Fudan University Shanghai Cancer Center, 200032, Shanghai, China. yanwj@fudan.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe biological functions of mitochondria play a role in the occurrence and development of breast cancer, however, the causal relationship between them remains unclear.

methodsGenetic instruments for mitochondrial biology and breast cancer were sourced from two genome-wide association studies (GWAS). Causal associations were assessed using Mendelian randomization analysis and validated through heterogeneity and sensitivity analyses. Additionally, the causal relationship between the identified mitochondrial proteins and the survival rate of breast cancer patients was further verified using the Kaplan-Meier Plotter.

resultsAnalysis indicated causal associations between six mitochondrial proteins and breast cancer incidence. Inverse associations were found for ADP-ribose pyrophosphatase (ADPRase) and Cytochrome c oxidase subunit 8 A (COX8A), while positive correlations were observed for Pyruvate carboxylase (PC), rRNA methyltransferase 3 (MRM3), Cytochrome c oxidase assembly factor 3 homolog (COA3), and Diablo homolog (DIABLO).

conclusionA causal relationship between mitochondrial biology and breast cancer was established in this study. ADPRase and COX8A were identified as protective factors, whereas PC, MRM3, COA3, and DIABLO were identified as risk factors.

Indexed as

Breast cancerGenetic causalityMendelian randomizationMitochondrial biology

Identifiers

PMID41588143

DOI10.1007/s12672-026-04500-8

PMCPMC12917074

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