Evidence map›Paper›PMID 41588142›Full record

ArticleScientific reports2026

Modified Müller's muscle conjunctival resection combined with levator plication in moderate to severe congenital ptosis with poor levator function.

Amirhossein Aghajani, Seyed Mohsen Rafizadeh, Mohammad Taher Rajabi, Seyede Simindokht Hosseini, Hanieh Fakhredin, Hamidreza Ghanbari, Amin Zand

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Amirhossein AghajaniDepartment of Oculo-Facial Plastic and Reconstructive Surgery, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Seyed Mohsen RafizadehDepartment of Oculo-Facial Plastic and Reconstructive Surgery, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Mohammad Taher RajabiDepartment of Oculo-Facial Plastic and Reconstructive Surgery, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Seyede Simindokht HosseiniTranslational Ophthalmology Research Center, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Hanieh FakhredinFarabi Eye Hospital, Tehran University of Medical Sciences, Qazvin Square, Tehran, Iran. fakhredin.hanieh@gmail.com.
Hamidreza GhanbariFarabi Eye Hospital, Tehran University of Medical Sciences, Qazvin Square, Tehran, Iran.
Amin ZandDepartment of Oculo-Facial Plastic and Reconstructive Surgery, Farabi Eye Hospital, Tehran University of Medical Sciences, Tehran, Iran.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To present a modified surgical technique for the correction of moderate to severe congenital ptosis with poor levator function. This prospective case series included 34 eyes from 34 patients with unilateral moderate to severe congenital ptosis, defined as marginal reflex distance-1 (MRD-1, the distance from the corneal light reflex to the upper eyelid margin in primary gaze) ≤ 2 mm and levator function (LF) ≤ 5 mm. The surgical approach combined Müller's muscle conjunctival resection with an extended range (12-17 mm) and levator plication. An "ideal" response was defined as a postoperative inter-eyelid MRD-1 difference of ≤ 0.5 mm, while an inter-eyelid MRD-1 difference of 0.5-1 mm was considered an "acceptable" response. Secondary outcomes included achieving an open visual axis. Eyelid contour, defined as the symmetry and smooth curvature of the upper eyelid margin relative to the contralateral eyelid, was objectively graded as excellent, good, fair, or poor based on curvature and symmetry with the contralateral eyelid. At the 6-month follow-up, the overall success rate was 76.5%, with 26.5% achieving an ideal response and 50.0% achieving an acceptable response. Among the 25 cases with visual axis obstruction due to ptosis, only 1 case (4%) failed to achieve an unobstructed visual axis at 6 months. The inter-observer agreement for eyelid contour grading was almost perfect, with a κ = 0.86. Excellent eyelid contour was achieved in 73.5% of cases at the 6-month follow-up. This modified surgical technique demonstrates favorable functional and aesthetic outcomes for treating moderate to severe congenital ptosis in young adults with poor levator function. Nevertheless, the study did not assess lash ptosis as a parameter, and potential preoperative predictive factors that may influence postoperative outcomes were not evaluated, representing important limitations.

Indexed as

BlepharoplastyBlepharoptosisConjunctivaEyelidsOculomotor MusclesAdolescentAdultChildChild, PreschoolFemaleHumansMaleProspective StudiesTreatment OutcomeYoung AdultCongenital ptosisEyelid contourLevator plicationMMCRMüller’s muscle conjunctival resectionPtosis surgery

Identifiers

PMID41588142
PMCPMC12905305

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.