Evidence map›Paper›PMID 41588078›Full record

ArticleScientific reports2026

Assessment of the biological efficacy of gold Nannochloropsis oculata nano-extract against lithium-induced toxicity in rats.

Randa Abdel-Salam Bekheit, Wael Mahmoud Aboulthana, Waleed Mohamed Serag

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Randa Abdel-Salam BekheitChemistry Department (Biochemistry Branch), Faculty of Science, Suez University, P.O. 43518, Suez, Egypt.
Wael Mahmoud AboulthanaBiochemistry Department, Biotechnology Research Institute, National Research Centre, 33 El Bohouth St., P.O. 12622, Dokki, Giza, Egypt. wmkamel83@hotmail.com.
Waleed Mohamed SeragChemistry Department (Biochemistry Branch), Faculty of Science, Suez University, P.O. 43518, Suez, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chronic renal impairment can be caused by prolonged exposure to lithium (Li), which is considered a prototype medication for the treatment of bipolar disorders (BDs). The current study aimed to enhance the biological efficacy of biosynthesized gold nanoparticles (Au-NPs) using an algal extract from Nannochloropsis oculata to mitigate the neurotoxicity and kidney damage induced by Li in rats. The kidney and brain tissues were analyzed using conventional biochemical tests to assess oxidative stress and inflammatory responses. Electrophoretic techniques were used to examine native protein and isoenzyme patterns. Histopathological analysis was conducted on both tissues. mRNA expression levels of inflammatory markers (NF-κB, IL-6, and IL-1β) and antioxidant enzymes (SOD1, CAT, and GPx1) were also measured. The study found that the gold N. oculata nano-extract restored normal hematological and biochemical parameters that were affected by an injection of lithium carbonate (Li

Indexed as

GoldLithiumLithium CarbonateMetal NanoparticlesStramenopilesAnimalsAntioxidantsBrainKidneyMaleOxidative StressRatsAntioxidantsGoldLithiumLithium CarbonateElectrophoresisGene expressionGold nanoparticlesGreen nanotechnologyLithium toxicityNannochloropsis oculata

Identifiers

PMID41588078
PMCPMC12835123

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.