ArticleLeukemia2026
Phf6 truncating mutation drives leukemogenesis via disrupted epigenetic regulation in mice.
Ying Guo, Pinpin Sui, Hui Yang, Ganqian Zhu, Ying Li, Shi Chen, Yuehui Zhao, Guo Ge, Yusra A Eisa, Caroline R Delma and 5 more
Abstract read
In one paragraphArticle in Leukemia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
15 authors.
Ying Guo *Department of Cell Systems & Anatomy, University of Texas Health San Antonio, San Antonio, TX, USA.ORCID 0000-0002-4423-113X Pinpin Sui *Department of Cell Systems & Anatomy, University of Texas Health San Antonio, San Antonio, TX, USA.ORCID 0000-0003-3779-9592 Hui Yang *Department of Cell Systems & Anatomy, University of Texas Health San Antonio, San Antonio, TX, USA.
Ganqian ZhuDepartment of Molecular Medicine, University of Texas Health San Antonio, San Antonio, TX, USA.
Ying LiDepartment of Molecular Medicine, University of Texas Health San Antonio, San Antonio, TX, USA.ORCID 0000-0002-3308-906X Shi ChenDepartment of Molecular Medicine, University of Texas Health San Antonio, San Antonio, TX, USA.
Yuehui ZhaoDepartment of Genetics, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Guo GeDepartment of Cell Systems & Anatomy, University of Texas Health San Antonio, San Antonio, TX, USA.ORCID 0000-0002-6362-772X Yusra A EisaDepartment of Cell Systems & Anatomy, University of Texas Health San Antonio, San Antonio, TX, USA.
Caroline R DelmaDepartment of Cell Systems & Anatomy, University of Texas Health San Antonio, San Antonio, TX, USA.
Peng ZhangDepartment of Cell Systems & Anatomy, University of Texas Health San Antonio, San Antonio, TX, USA.ORCID 0000-0002-3394-6922 Feng-Chun YangDepartment of Cell Systems & Anatomy, University of Texas Health San Antonio, San Antonio, TX, USA. yangf1@uthscsa.edu.ORCID 0000-0001-8524-4095 Funding
U.S. Department of Health & Human Services | NIH | National Cancer Institute (NCI) CA172408U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL145883U.S. Department of Health & Human Services | NIH | National Heart, Lung, and Blood Institute (NHLBI) HL149318
6 · The paper itselfAbstract
Somatic mutations in PHF6 (PHD finger protein 6) are common in hematologic malignancies and confer worse overall survival in acute myeloid leukemia patients. These mutations are predominantly frameshift or nonsense variants, resulting in a truncated PHF6 protein. However, the specific role of truncated PHF6 in leukemogenesis remains unclear. Here, we generated a transgenic mouse model, Phf6
Indexed as
CarcinogenesisEpigenesis, GeneticLeukemiaMutationRepressor ProteinsAnimalsCell DifferentiationHematopoietic Stem CellsHumansMiceMice, TransgenicPHF6 protein, humanPhf6 protein, mouseRepressor Proteins
What OpenQuestion holds
Textmetadata
Read underepoch 390