Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registry
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Briana H Greer *Department of Biological Sciences, Vanderbilt University, Nashville, TN, 37232, USA.ORCID 0009-0005-4448-542X
Javier Mendia-Garcia *Department of Macromolecular Structures, Centro Nacional de Biotecnología (CNB), CSIC, Madrid, Spain.ORCID 0009-0009-3408-6811
Elwood A Mullins *Department of Biological Sciences, Vanderbilt University, Nashville, TN, 37232, USA.ORCID 0000-0003-3834-1065
Emma M PeacockDepartment of Biological Sciences, Vanderbilt University, Nashville, TN, 37232, USA.ORCID 0009-0006-3801-9841
Sander K HaighDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA.
Carl J SchiltzDepartment of Biological Sciences, Vanderbilt University, Nashville, TN, 37232, USA.
Clara Aicart-RamosDepartment of Macromolecular Structures, Centro Nacional de Biotecnología (CNB), CSIC, Madrid, Spain.ORCID 0000-0002-1114-4259
Miaw-Sheue TsaiBiological Systems and Engineering Division, Lawrence Berkeley National Laboratory, Berkeley, CA, 94720, USA.ORCID 0000-0003-3239-5724
David CortezDepartment of Biochemistry, Vanderbilt University School of Medicine, Nashville, TN, 37232, USA.ORCID 0000-0003-0154-140X
Fernando Moreno-HerreroDepartment of Macromolecular Structures, Centro Nacional de Biotecnología (CNB), CSIC, Madrid, Spain.ORCID 0000-0003-4083-1709
Brandt F EichmanDepartment of Biological Sciences, Vanderbilt University, Nashville, TN, 37232, USA. brandt.eichman@vanderbilt.edu.ORCID 0000-0002-0965-2297
Funding
Transcription-Coupled & Replication-Associated Excision RepairP01CA092584 · NCI · UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB · PI John A. Tainer · 2001 to 2026
$89.6M
TRAINING PROGRAM IN ENVIRONMENTAL TOXICOLOGYT32ES007028 · NIEHS · VANDERBILT UNIVERSITY · PI F PETER Guengerich, Fiona Edith Harrison · 1985 to 2026
$15.7M
BIOCHEMICAL &CHEMICAL TRAINING FOR CANCER RESEARCHT32CA009582 · NCI · VANDERBILT UNIVERSITY · PI David K Cortez · 1987 to 2026
$8.8M
MOLECULAR BIOPHYSICS TRAINING PROGRAM AT VANDERBILTT32GM008320 · NIGMS · VANDERBILT UNIVERSITY · PI CHAZIN, WALTER J. · 1989 to 2023
$7.9M
Analysis of the Replication Stress ResponseR01GM116616 · NIGMS · VANDERBILT UNIVERSITY · PI David K Cortez · 2015 to 2026
$5.4M
The DNA replication-repair interface: mechanisms and regulationR35GM136401 · NIGMS · VANDERBILT UNIVERSITY · PI Brandt F Eichman · 2020 to 2026
$4.3M
Cellular, Biochemical and Molecular Sciences Training ProgramT32GM137793 · NIGMS · VANDERBILT UNIVERSITY · PI Katherine Louise Friedman, TODD R GRAHAM · 2021 to 2026
$2.6M
Thermo Scientific Glacios cryo-TEMS10OD030292 · OD · VANDERBILT UNIVERSITY · PI NAKAGAWA, TERUNAGA · 2021 to 2021
$2.0M
F.M.H. laboratoryNCI NIH HHS P01 CA092584NCI NIH HHS T32 CA009582NIEHS NIH HHS T32 ES007028NIGMS NIH HHS R01 GM116616NIGMS NIH HHS R35 GM136401NIGMS NIH HHS T32 GM008320NIGMS NIH HHS T32 GM137793NIH HHS S10 OD030292Spanish Ministry of UniversitiesU.S. Department of Health & Human Services | NIH | National Institute of General Medical Sciences (NIGMS) R35GM136401
6 · The paper itself
Abstract
Replication fork reversal helps maintain genomic stability during replication stress. F-box helicase 1 (FBH1) catalyzes fork reversal and is an SCF (SKP-CUL1-F-box) E3 ubiquitin ligase that limits RAD51 association with chromatin. Here, we show that preferential binding of SCF
Indexed as
DNA ReplicationF-Box ProteinsRad51 RecombinaseSKP Cullin F-Box Protein LigasesCryoelectron MicroscopyDNA-Binding ProteinsDNA HelicasesDNA, Single-StrandedHumansModels, MolecularProtein BindingUbiquitinationDNA-Binding ProteinsDNA HelicasesDNA, Single-StrandedFBH1 protein, humanF-Box ProteinsRAD51 protein, humanRad51 RecombinaseSKP Cullin F-Box Protein Ligases
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.
Structural basis for fork reversal and RAD51 regulation by the SCF ubiquitin ligase complex of F-box helicase 1. · full record | OpenQuestion