ArticleRNA (New York, N.Y.)2026
Structure-informed mutagenesis identifies combinatorial contributions to mouse insulin receptor IRES function.
Article in RNA (New York, N.Y.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Cells under stress shift their proteome by repressing cap-dependent translation initiation. RNA elements called internal ribosome entry sites (IRES) can allow key cellular transcripts to remain efficiently translated to support an effective stress response. We previously determined that the 5' untranslated region (5'UTR) of the insulin receptor mRNA possesses a capacity for IRES activity that is conserved from insects to mammals. Well-characterized IRESs depend on RNA structures that reduce the protein requirements for translation initiation, thus circumventing translation inhibition. While there are several examples of viral IRES structures solved in vitro, the RNA secondary structures of cellular IRESs remain elusive, and little information exists about the secondary structures of these RNAs in vivo. Here we probe the secondary structure of the
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