ArticleVox sanguinis2026
From platelets to particles: Optimizing extracellular vesicle isolation in a National Blood Centre.
Article in Vox sanguinis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
1 citing paper in PubMed.
- Platelet-derived mitochondrial transfer in cancer metastasis: mechanisms, functional consequences, and translational opportunities.Clinical & experimental metastasis · 2026Review
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Authors and funding
6 authors.
Funding
Abstract
BACKGROUND AND
objectivesPlatelet-derived extracellular vesicles (PEVs) are submicron, membrane-bound particles released upon platelet activation, with a recognized role in haemostasis, inflammation and immunoregulation. PEVs remain insufficiently characterized in blood products. This study compared four isolation methods to evaluate their impact on PEV yield, purity and characteristics, aiming to identify a practical approach for transfusion service workflows. MATERIALS AND
methodsPEVs were isolated from expired single-donor aphaeresis platelet concentrates (n = 12) using methods based on different isolation principles: ultracentrifugation (UC), size exclusion chromatography (SEC), mixed size/charge separation (hybrid) and an affinity-based spin column method (affinity). Size, number and biochemical marker expression of all extracellular vesicle (EV) isolates were assessed.
resultsPEVs were successfully isolated by all methods, although at varying yields. The overall size distribution of all methods was similar, although SEC and affinity methods isolated PEVs with the largest diameters. PEV isolated by the affinity method had the lowest lipid:protein ratio, consistent with high purity. No differences in expression of EV marker CD9 or platelet activation marker CD42b were found.
conclusionComparison of the physical and biochemical characteristics of the PEVs isolated by each method reveals that the affinity method was superior to other methods. In addition, its simplicity, cost effectiveness and accessibility make it a practical option for blood transfusion services to further explore the role of PEVs.
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