Evidence map›Paper›PMID 41587741›Full record

ArticlePsychological medicine2026

The causal interplay between depression and alcohol use from adolescence to young adulthood: a Mendelian randomization study.

Xuefei Wang, Shitong Xiang, Jujiao Kang, Rongquan Zhai, Chen Zheng, Tobias Banaschewski, Arun L W Bokde, Rüdiger Brühl, Sylvane Desrivières, Herta Flor and 21 more

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Article in Psychological medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

31 authors.

Xuefei WangInstitute of Science and Technology for Brain-Inspired Intelligence (ISTBI), https://ror.org/013q1eq08Fudan University, Shanghai, China.ORCID https://orcid.org/0009-0004-4014-2094
Shitong XiangInstitute of Science and Technology for Brain-Inspired Intelligence (ISTBI), https://ror.org/013q1eq08Fudan University, Shanghai, China.
Jujiao KangInstitute of Science and Technology for Brain-Inspired Intelligence (ISTBI), https://ror.org/013q1eq08Fudan University, Shanghai, China.
Rongquan ZhaiInstitute of Science and Technology for Brain-Inspired Intelligence (ISTBI), https://ror.org/013q1eq08Fudan University, Shanghai, China.ORCID https://orcid.org/0009-0009-8252-6965
Chen ZhengInstitute of Science and Technology for Brain-Inspired Intelligence (ISTBI), https://ror.org/013q1eq08Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0002-9373-6433
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry and Psychotherapy, https://ror.org/038t36y30Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, German Center for Mental Health (DZPG), partner site Mannheim-Heidelberg-Ulm, Mannheim, Germany.ORCID https://orcid.org/0000-0003-4595-1144
Arun L W BokdeDiscipline of Psychiatry, School of Medicine and Trinity College Institute of Neuroscience, https://ror.org/02tyrky19Trinity College Dublin, Dublin, Ireland.ORCID https://orcid.org/0000-0003-0114-4914
Rüdiger Brühlhttps://ror.org/05r3f7h03Physikalisch-Technische Bundesanstalt (PTB), Braunschweig and Berlin, Germany.ORCID https://orcid.org/0000-0003-0111-5996
Sylvane DesrivièresSocial, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry, Psychology & Neuroscience, https://ror.org/0220mzb33King's College, London, UK.
Herta FlorInstitute of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, https://ror.org/038t36y30Heidelberg University, Mannheim, Germany.
Hugh GaravanDepartments of Psychiatry and Psychology, https://ror.org/0155zta11University of Vermont, Burlington, VT, USA.
Penny GowlandSir Peter Mansfield Imaging Centre School of Physics and Astronomy, https://ror.org/01ee9ar58University of Nottingham, University Park, Nottingham, UK.
Antoine GrigisNeuroSpin, https://ror.org/028rypz17CEA, Université Paris-Saclay, Gif-sur-Yvette, France.
Andreas HeinzDepartment of Psychiatry and Psychotherapy, https://ror.org/03a1kwz48University of Tübingen, Germany; German Center for Mental Health (DZPG), Site Tübingen, Germany.
Jean-Luc MartinotInstitut National de la Santé et de la Recherce Médicale, INSERM U A10 "Trajectoires développementales & psychiatrie", https://ror.org/03xjwb503University Paris-Saclay, Ecole Normale Supérieure Paris-Saclay, CNRS; Centre Borelli, Gif-sur-Yvette, France.
Marie-Laure Paillère MartinotInstitut National de la Santé et de la Recherce Médicale, INSERM U A10 "Trajectoires développementales & psychiatrie", https://ror.org/03xjwb503University Paris-Saclay, Ecole Normale Supérieure Paris-Saclay, CNRS; Centre Borelli, Gif-sur-Yvette, France.
Eric ArtigesInstitut National de la Santé et de la Recherce Médicale, INSERM U A10 "Trajectoires développementales & psychiatrie", https://ror.org/03xjwb503University Paris-Saclay, Ecole Normale Supérieure Paris-Saclay, CNRS; Centre Borelli, Gif-sur-Yvette, France.ORCID https://orcid.org/0000-0003-4461-7646
Frauke NeesInstitute of Medical Psychology, Ludwig-Maximilians-Universität (LMU) in Munich, Munich, Germany.ORCID https://orcid.org/0000-0002-7796-8234
Dimitri Papadopoulos OrfanosDepartment of Psychology, School of Social Sciences, https://ror.org/031bsb921University of Mannheim, Mannheim, Germany.
Tomáš PausDepartment of Psychiatry and Neuroscience, Faculty of Medicine and Centre Hospitalier Universitaire Sainte-Justine, University of Montreal, Montreal, QC, Canada.
Luise PoustkaDepartment of Child and Adolescent Psychiatry, Center for Psychosocial Medicine, https://ror.org/013czdx64University Hospital Heidelberg, Heidelberg, Germany.
Michael N SmolkaDepartment of Psychiatry and Psychotherapy, https://ror.org/05r3f7h03Technische Universität Dresden, Dresden, Germany.ORCID https://orcid.org/0000-0001-5398-5569
Sarah HohmannDepartment of Child and Adolescent Psychiatry and Psychotherapy, https://ror.org/038t36y30Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, German Center for Mental Health (DZPG), partner site Mannheim-Heidelberg-Ulm, Mannheim, Germany.
Nathalie HolzDepartment of Child and Adolescent Psychiatry and Psychotherapy, https://ror.org/038t36y30Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, German Center for Mental Health (DZPG), partner site Mannheim-Heidelberg-Ulm, Mannheim, Germany.
Nilakshi VaidyaCentre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Psychotherapy, https://ror.org/001w7jn25Charité Universitätsmedizin Berlin, Germany.
Henrik WalterDepartment of Psychiatry and Psychotherapy CCM, https://ror.org/001w7jn25Charité - Universitätsmedizin Berlin, corporate member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany.
Robert WhelanSchool of Psychology and Global Brain Health Institute, https://ror.org/02tyrky19Trinity College Dublin, Ireland.
Gunter SchumannCentre for Population Neuroscience and Stratified Medicine (PONS), Department of Psychiatry and Psychotherapy, https://ror.org/001w7jn25Charité Universitätsmedizin Berlin, Germany.
IMAGEN Consortium
Tianye JiaInstitute of Science and Technology for Brain-Inspired Intelligence (ISTBI), https://ror.org/013q1eq08Fudan University, Shanghai, China.ORCID https://orcid.org/0000-0001-5399-2953
Jianfeng FengInstitute of Science and Technology for Brain-Inspired Intelligence (ISTBI), https://ror.org/013q1eq08Fudan University, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDepression is often comorbid with alcohol use problems, and sex differences may further complicate this interplay.

methodsWe conducted a longitudinal study using a large European adolescent cohort assessed at ages 14 (baseline, BL), 16 (follow-up 1, FU1), 19 (follow-up 2, FU2), and 23 (follow-up 3, FU3). Depression and alcohol use were measured using standardized behavioral scales. Cross-lagged analysis, improved Mendelian randomization (MR) analysis, and mediation analysis were conducted to infer the causal interplay.

results2110 adolescents were included at baseline (49% male). Depression and alcohol consumption demonstrated a significant positive correlation (

conclusionsDepression may predict future alcohol use problems, whereas moderate alcohol consumption might alleviate depressive symptoms, especially in females.

Indexed as

Alcohol DrinkingDepressionAdolescentComorbidityEuropeFemaleHumansLongitudinal StudiesMaleMendelian Randomization AnalysisYoung Adultadolescencealcohol use disordercausal interplaycross-lagged panel modelgenetic instrumental variableslongitudinal studymediation analysisMendelian randomizationmood disorderpolygenic risk scoresself-medicationsex differences

Identifiers

PMID41587741
PMCPMC12885341

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.