ArticleJournal of advanced research2026
Longitudinal dynamics in frailty and incident all-cause dementia: a multicohort study.
Article in Journal of advanced research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
3 citing papers in PubMed.
- Dynamic frailty exposure and cognitive aging trajectories: A multicohort study.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Longitudinal Changes in Frailty and Major Adverse Cardiovascular Events in Patients With Coronary Heart Disease.Journal of the American Heart Association · 2026Article
- Associations of long-term average and variability of estimated glucose disposal rate with frailty progression: evidence from two prospective cohorts.Journal of translational medicine · 2026Article
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionFrailty changes over time, but how these changes relate to the risk of dementia remains uncertain.
objectiveTo explore the temporal relationship between dynamic changes in frailty and incident all-cause dementia.
methodsWe included adults aged ≥ 60 years from four prospective cohorts in this pooled analysis. Frailty was assessed using a modified Fried phenotype at two separate time points, allowing the identification of longitudinal frailty transition patterns. The outcome was all-cause dementia, identified through active follow-up assessments or passive data collection. Hazard ratios (HRs) and 95% confidence intervals (CIs) were derived from Cox proportional hazards analyses.
resultsAmong 15,897 participants (51.3% female, mean age: 66.9 years), 1015 developed incident dementia over 131,621.3 person-years of follow-up. An increased risk of dementia was observed among robust participants who progressed to pre-frail/frail status, compared to those with stable robustness (pooled HR: 1.62, 95% CI: 1.06-2.47; I
conclusionsProgression in frailty was associated with an increased risk of dementia, while reversal of pre-frailty reduced the risk. Our results highlight the importance of continuous monitoring and personalized interventions for managing frailty in older adults.
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