Evidence map›Paper›PMID 41587642›Full record

ArticleNeurobiology of disease2026

Pharmacological manipulation of nested oscillations in human iPSC-derived 2D neuronal networks.

Deborah Pré, Christian Cazares, Alexander T Wooten, Haowen Zhou, Isabel Onofre, Ashley Neil, Todd Logan, Ruilong Hu, Jan H Lui, Bradley Voytek and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neurobiology of disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Deborah PréConrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Christian CazaresDepartment of Cognitive Science, University of California, San Diego, La Jolla, CA 92037, USA.
Alexander T WootenConrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Haowen ZhouConrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Isabel OnofreConrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Ashley NeilConrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA.
Todd LoganBioMarin Pharmaceutical, 105 Digital Drive, Novato, CA 94949, USA.
Ruilong HuBioMarin Pharmaceutical, 105 Digital Drive, Novato, CA 94949, USA.
Jan H LuiBioMarin Pharmaceutical, 105 Digital Drive, Novato, CA 94949, USA.
Bradley VoytekDepartment of Cognitive Science, University of California, San Diego, La Jolla, CA 92037, USA; Halıcıoğlu Data Science Institute, University of California, San Diego, La Jolla, CA 92037, USA; Kavli Institute for Brain and Mind, University of California, San Diego, La Jolla, CA 92037, USA. Electronic address: voytek@ucsd.edu.
Anne G BangConrad Prebys Center for Chemical Genomics, Sanford Burnham Prebys Medical Discovery Institute, 10901 North Torrey Pines Road, La Jolla, CA 92037, USA. Electronic address: abang@sbpdiscovery.org.

Funding

UCSD/SDSU IRACDAK12GM068524 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI TREJO, JOANN · 2003 to 2025
$24.4M
Role of CACNA1C - a shared risk gene in neuropsychiatric disordersU19MH106434 · NIMH · UNIVERSITY OF PENNSYLVANIA · PI GAGE, FRED H · 2016 to 2020
$13.8M
Investigating Orbitofrontal Circuit Mechanisms of Social Rank and Dominance BehaviorK00MH132569 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CAZARES, CHRISTIAN · 2022 to 2025
$318k
Burroughs Wellcome FundNIGMS NIH HHS K12 GM068524NIMH NIH HHS K00 MH132569NIMH NIH HHS U19 MH106434
6 · The paper itself

Abstract

Dynamically coupled neural networks are fundamental to human cognition and behavior and are disrupted in neurodevelopmental disorders. The formation and dissolution of functional networks is thought to be driven by synchronized oscillatory bursts across large populations of neurons. The mechanisms driving the emergence of these rhythms, known as oscillogenesis, are not well understood, particularly in the human brain. Using multi-electrode arrays, we investigated oscillogenesis in human induced pluripotent stem cell 2D neural cultures at different developmental stages and under pharmacological challenges. We found that cultures exhibited nested oscillations that were reduced by GABAA receptor blockade and emerged earlier when the proportion of GABAergic neurons was increased. Pharmacological manipulations of voltage-gated potassium channels and cholinergic receptors modulated the pattern of nested oscillations. These results reveal the capacity of these 2D cultures to model oscillogenesis, and underscore the need for their continued refinement, paving the way for linking systems-level neural networks to human cognition and disease.

Indexed as

Induced Pluripotent Stem CellsNerve NetNeuronsCells, CulturedGABA-A Receptor AntagonistsGABAergic NeuronsHumansPotassium Channel BlockersPotassium Channels, Voltage-GatedGABA-A Receptor AntagonistsPotassium Channel BlockersPotassium Channels, Voltage-GatedCholinergic systemExcitation/inhibitionHuman induced pluripotent stem cell (hiPSC)Multi-electrode arrayOscillationsPotassium channels

Identifiers

PMID41587642
PMCPMC13110928

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.