Evidence map›Paper›PMID 41587307›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Mammals that can develop type 2 diabetes have a similarly structured β-sheet amyloid oligomer.

Brynn E LeMasters, Caitlyn R Fields, Justin P Lomont, Farzaneh Chalyavi, Kacie L Rich, Donald S Stapleton, Sidney S Dicke, Mark P Keller, Alan D Attie, Martin T Zanni

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Amylin: A Multi-Functional Pancreatic Hormone-A Review.Diabetes, obesity & metabolism · 2026
    Review
  2. Mammals that can develop type 2 diabetes have a similarly structured β-sheet amyloid oligomer.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  3. A structural model of toxic amyloid oligomers involved in type 2 diabetes.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Brynn E LeMasters *Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706.ORCID 0000-0001-9910-6953
Caitlyn R Fields *Department of Chemistry, University of Wisconsin-Madison, Madison, WI 53706.
Justin P LomontDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI 53706.ORCID 0000-0003-1106-3683
Farzaneh ChalyaviDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI 53706.
Kacie L RichDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI 53706.
Donald S StapletonDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706.
Sidney S DickeDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI 53706.
Mark P KellerDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706.
Alan D AttieDepartment of Biochemistry, University of Wisconsin-Madison, Madison, WI 53706.
Martin T ZanniDepartment of Chemistry, University of Wisconsin-Madison, Madison, WI 53706.

Funding

Structural mechanism of diabetic amyloid formationR01DK079895 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI Martin T Zanni · 2008 to 2026
$7.7M
The Diversity Outbred Diabetes ProjectR01DK101573 · NIDDK · UNIVERSITY OF WISCONSIN-MADISON · PI Alan D Attie · 2014 to 2026
$5.3M
Predoctoral Training in Molecular BiophysicsT32GM130550 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI SENES, ALESSANDRO · 2019 to 2023
$1.5M
Predoctoral Training in Molecular BiophysicsT32GM158463 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI Silvia Cavagnero, Alessandro Senes · 2025 to 2026
$1.3M
HHS | NIH (NIH) DK101573HHS | NIH (NIH) R01DK079895HHS | NIH (NIH) T32GM130550HHS | NIH (NIH) T32GM158463NIDDK NIH HHS R01 DK079895NIDDK NIH HHS R01 DK101573NIGMS NIH HHS T32 GM130550NIGMS NIH HHS T32 GM158463
6 · The paper itself

Abstract

Some mammals develop amyloid plaques and type 2 diabetes, much like humans, depending on the sequence of their islet amyloid polypeptide (IAPP). In humans, IAPP forms a toxic oligomer with a parallel β-sheet across residues

Indexed as

AmyloidDiabetes Mellitus, Type 2Islet Amyloid PolypeptideAmino Acid SequenceAnimalsHumansProtein Conformation, beta-StrandProtein Structure, SecondaryAmyloidIslet Amyloid Polypeptideamyloid oligomeramyloid structureultrafast 2D IR spectroscopy

Identifiers

PMID41587307
PMCPMC12867628

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.