Evidence map›Paper›PMID 41587305›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2026

Subcellular mass spectrometry reveals proteome remodeling in an asymmetrically dividing (frog) embryonic stem cell.

Bowen Shen, Leena R Pade, Fei Zhou, Peter Nemes

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Subcellular mass spectrometry reveals proteome remodeling in an asymmetrically dividing (frog) embryonic stem cell.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Bowen Shen *Department of Chemistry & Biochemistry, University of Maryland, College Park, MD 20742.
Leena R Pade *Department of Chemistry & Biochemistry, University of Maryland, College Park, MD 20742.ORCID 0000-0003-4081-3535
Fei ZhouDepartment of Chemistry & Biochemistry, University of Maryland, College Park, MD 20742.
Peter NemesDepartment of Chemistry & Biochemistry, University of Maryland, College Park, MD 20742.ORCID 0000-0002-4704-4997

Funding

Sub-Cellular Mass Spectrometry Discoveries: Metabolic Encoding of the Embryonic Body PlanR35GM124755 · NIGMS · UNIV OF MARYLAND, COLLEGE PARK · PI Peter Nemes · 2017 to 2026
$3.8M
Arnold and Mabel Beckman Foundation (AMBF) Beckman Young Investigator awardChan-Zuckerberg Initiative AwardCosmos Club Foundation FellowshipHHS | NIH | National Institute of General Medical Sciences (NIGMS) R35GM124755NIGMS NIH HHS R35 GM124755
6 · The paper itself

Abstract

Subcellular proteomics maps protein localization within restricted domains of a cell, complementing high-resolution imaging by expanding the number of proteins that can be profiled at once. Achieving this at depth from subcellular inputs remains challenging. Here, we advance microprobe capillary electrophoresis-mass spectrometry (CE-MS) with trapped ion mobility spectrometry and data-independent acquisition (diaPASEF) to quantify more than a thousand proteins from opposite poles of an asymmetrically dividing embryonic blastomere in live

Indexed as

Asymmetric Cell DivisionEmbryonic Stem CellsMass SpectrometryProteomeXenopus laevisXenopus ProteinsAnimalsBlastomeresHeLa CellsHumansProteomicsProteomeXenopus Proteinsblastomeremass spectrometryproteomicssubcellularXenopus

Identifiers

PMID41587305
PMCPMC12867692

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.