ArticleIEEE transactions on bio-medical engineering2026
The Effect of von Willebrand Disease on Platelet Adhesion Dynamics: Correlating a Multiscale Platelet Model to In Vitro Results.
Article in IEEE transactions on bio-medical engineering, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectiveVon Willebrand Disease (VWD), the most common inherited bleeding disorder affecting 0.1% to 1% of the population, causes extensive mucocutaneous bleeding across various clinical contexts. Von Willebrand Factor (vWF) plays a critical role in hemostasis by mediating platelet adhesion under high shear stress conditions. We simulated platelet-vWF interactions to investigate adhesion dynamics in VWD using a multiscale modeling approach combining Dissipative Particle Dynamics (DPD) and Coarse-Grained Molecular Dynamics (CGMD).
methodsOur platelet model provides high-resolution insights into adhesion mechanics by representing the platelet as a complex, deformable cellular entity comprising intricate membrane and subcellular components that capture the nuanced biomechanical behavior of platelets under flow conditions.
resultsSimulations under 30 dyne/cm
conclusionsThis work provides quantitative insights into the molecular mechanisms underlying platelet adhesion in VWD through our advanced CGMD model. SIGNIFICANCE: Our findings establish a comprehensive framework for understanding cellular adhesion processes in biofluid environments, potentially informing therapeutic strategies for bleeding disorders and thrombotic conditions.
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