Evidence map›Paper›PMID 41587080›Full record

ArticleeLife2026

Axonal distribution of mitochondria maintains neuronal autophagy during aging via eIF2β.

Kanako Shinno, Yuri Miura, Koichi M Iijima, Emiko Suzuki, Kanae Ando

Abstract read
In one paragraph

Article in eLife, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
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  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors.

Kanako ShinnoDepartment of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Hachioji, Japan.ORCID https://orcid.org/0009-0002-7114-7686
Yuri MiuraResearch Team for Mechanism of Aging, Tokyo Metropolitan Institute for Geriatrics and Gerontology, Itabashi, Japan.ORCID https://orcid.org/0000-0003-1239-3780
Koichi M IijimaDepartment of Neurogenetics, National Center for Geriatrics and Gerontology, Obu, Japan.ORCID https://orcid.org/0000-0003-4794-1863
Emiko SuzukiDepartment of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Hachioji, Japan.ORCID https://orcid.org/0000-0002-4005-0542
Kanae AndoDepartment of Biological Sciences, Graduate School of Science, Tokyo Metropolitan University, Hachioji, Japan.ORCID https://orcid.org/0000-0002-3956-276X

Funding

Drosophila Transgenic RNAi Resource ProjectR01GM084947 · NIGMS · HARVARD MEDICAL SCHOOL · PI PERRIMON, NORBERT · 2008 to 2019
$9.8M
Japan Science Society Sasakawa Scientific Research Grant (2021-4087)Japan Society for the Promotion of Science JP19K21593Japan Society for the Promotion of Science JP24K02860National Institute of Genetics NIG-Joint 25A2019National Institute of Genetics NIG-JOINT 71A2018NIGMS NIH HHS R01 GM084947Tokyo Metropolitan University TMU strategic research fund for social engagement
6 · The paper itself

Abstract

Neuronal aging and neurodegenerative diseases are accompanied by proteostasis collapse, while the cellular factors that trigger it have not been identified. Impaired mitochondrial transport in the axon is another feature of aging and neurodegenerative diseases. Using

Indexed as

AgingAutophagyAxonsEukaryotic Initiation Factor-2Eukaryotic Initiation Factor-2BMitochondriaNeuronsAnimalsDrosophila melanogasterProteostasisEukaryotic Initiation Factor-2Eukaryotic Initiation Factor-2Bagingautophagycell biologyD. melanogastermitochondrianeuronal proteostasisprotein aggregationproteome

Identifiers

PMID41587080
PMCPMC12834499

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.