Evidence map›Paper›PMID 41587071›Full record

ArticleBlood2026

Uncovering the genomic complexity of PAX5 intragenic tandem multiplication via long-read and short-read sequencing.

Yanling Liu, Bensheng Ju, Li Dong, Melanie Loyd, Samuel W Brady, Rhonda Ries, Yuan Feng, Heather Mulder, Emily Plyler, Christian Deardorff and 25 more

Abstract read
In one paragraph

Article in Blood, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

35 authors.

Yanling LiuDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN.
Bensheng JuDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN.
Li DongDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN.
Melanie LoydHartwell Center for Biotechnology, St. Jude Children's Research Hospital, Memphis, TN.
Samuel W BradyDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN.
Rhonda RiesClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Yuan FengDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN.ORCID 0009-0007-8932-4405
Heather MulderDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN.
Emily PlylerDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN.ORCID 0000-0003-2642-1674
Christian DeardorffNationwide Children's Hospital, Columbus, OH.
Andrea McBrideNationwide Children's Hospital, Columbus, OH.
Tyler JonesNationwide Children's Hospital, Columbus, OH.ORCID 0009-0003-5254-3306
Alexis EckertNationwide Children's Hospital, Columbus, OH.
Pandurang KolekarDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN.ORCID 0000-0003-0044-0076
Li FanDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN.
Hanxia LiDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN.
Monta BrivibaDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN.ORCID 0000-0003-3031-2243
Huanbin ZhaoDepartment of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN.ORCID 0009-0001-4418-6770
Declan BennettDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN.ORCID 0000-0003-2614-0362
Geoff NealeHartwell Center for Biotechnology, St. Jude Children's Research Hospital, Memphis, TN.
Ti-Cheng ChangCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN.
Wenan ChenCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN.
Stanley PoundsDepartment of Biostatistics, St. Jude Children's Research Hospital, Memphis, TN.ORCID 0000-0002-9167-2114
Gang WuCenter for Applied Bioinformatics, St. Jude Children's Research Hospital, Memphis, TN.
Charles MullighanDepartment of Pathology, St. Jude Children's Research Hospital, Memphis, TN.ORCID 0000-0002-1871-1850
Paul GeeleherDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN.
Lingyun JiDepartment of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.ORCID 0000-0003-2500-1993
Jun J YangDepartment of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, TN.
Soheil MeshinchiClinical Research Division, Fred Hutchinson Cancer Research Center, Seattle, WA.
Patrick A BrownBeOne Medicines, Cambridge, MA.ORCID 0000-0002-8653-1069
William L CarrollDepartment of Pediatrics, NYU Langone Health, New York, NY.
Jinghui ZhangDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN.
Mignon L LohBen Towne Center for Childhood Cancer and Blood Disorders Research, Seattle Children's Research Institute, University of Washington, Seattle, WA.ORCID 0000-0003-4099-4700
John EastonDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN.ORCID 0000-0003-4503-6608
Xiaotu MaDepartment of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN.ORCID 0000-0002-6233-2145

Funding

NCTN BIQSFP ANBL1531 (NRT)U10CA180886 · NCI · PUBLIC HEALTH INSTITUTE · PI Douglas S. Hawkins · 2014 to 2026
$390.6M
COG SDMC - Statistics CoreU10CA180899 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI TODD A ALONZO · 2014 to 2026
$132.8M
Tracking Therapy-Resistant Alterations in Childhood Acute Lymphoblastic LeukemiaR01CA273326 · NCI · ST. JUDE CHILDREN'S RESEARCH HOSPITAL · PI Xiaotu Ma · 2022 to 2026
$2.1M
NCI NIH HHS P30-CA021765NCI NIH HHS R01 CA273326NCI NIH HHS R01-CA293587NCI NIH HHS U10 CA180886NCI NIH HHS U10 CA180899
6 · The paper itself

Abstract

abstractBy integrating short-read whole-genome sequencing and RNA sequencing (RNA-seq) data with long-read RNA-seq, we dissect the complex genomic architecture of PAX5 intragenic tandem multiplication, revealing that these complex rearrangements result in in-frame transcripts that likely encode proteins with altered domains.

Indexed as

PAX5 Transcription FactorTandem Repeat SequencesAnimalsGenomicsHumansSequence Analysis, RNAWhole Genome SequencingPAX5 protein, humanPAX5 Transcription Factor

Identifiers

PMID41587071
PMCPMC13077480

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.