Evidence map›Paper›PMID 41586937›Full record

ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026

Comprehensive evaluation and analysis of pituitary hormones in male patients with non-functional pituitary adenoma during the perioperative period.

Jiansheng Zhong, Yuyang Chen, Wenxian Yang, Pengwei Hou, Jun Li, Ziqi Li, Haixiang Li, Liangfeng Wei, Shousen Wang

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Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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9 authors.

Jiansheng ZhongDepartment of Clinical Medicine, Fujian Medical University, Fuzhou 900 Hospital, Fuzhou, China.
Yuyang ChenDepartment of Clinical Medicine, Fujian Medical University, Fuzhou 900 Hospital, Fuzhou, China.
Wenxian YangBengbu Medical University, Bengbu, China.
Pengwei HouJinjiang Municipal Hospital (Shanghai Sixth People's Hospital Fujian Branch), Quanzhou, China.
Jun LiFujian Provincial Clinical Medical Research Center for Minimally Invasive Diagnosis and Treatment of Neurovascular Diseases, Fuzhou, China.
Ziqi LiDepartment of Clinical Medicine, Fujian Medical University, Fuzhou 900 Hospital, Fuzhou, China.
Haixiang LiXiamen University, Xiamen, China.
Liangfeng WeiDepartment of Clinical Medicine, Fujian Medical University, Fuzhou 900 Hospital, Fuzhou, China.
Shousen WangDepartment of Clinical Medicine, Fujian Medical University, Fuzhou 900 Hospital, Fuzhou, China. wshsen1965@126.com.ORCID http://orcid.org/0000-0001-5732-7846

Funding

Fujian Association for Science and Technology 2022Y2017Joint Logistics Medical Key Specialty Project LQZD-SW
6 · The paper itself

Abstract

objectiveTo analyze perioperative hormonal changes in male patients with non-functioning pituitary adenomas undergoing transsphenoidal surgery and establish a method for assessing adenopituitary function.

methodsWe retrospectively analyzed preoperative clinical and imaging data, and perioperative anterior pituitary hormone levels of 123 male non-functioning pituitary adenomas patients who underwent surgery from 2012 to 2022. Hormone scores were calculated using an inverse tangent function normalized to normal hormone levels (0-1). Total pituitary hormone score summed six hormones (GH, ACTH, TSH, PRL, FSH, LH) reflecting overall pituitary secretion. ROC curves and AUC were calculated for assessment.

resultsMost hormone levels (except GH, FSH) and total scores decreased postoperatively in large/giant adenoma groups, recovering by 3 months. Significant preoperative and postoperative differences were found in GH, TSH, LH, and total scores (P < 0.05). TSH, PRL, FSH, and total scores showed significant time-related changes, while GH, ACTH, and LH remained stable. Total scores differed significantly between patients with and without preoperative hypopituitarism (P < 0.001 for ACTH, FSH, LH, TSH). Prediction models had AUCs of 0.755 and 0.636 for patients without and with preoperative hypopituitarism, respectively.

conclusionsMale non-functioning pituitary adenomas patients experienced immediate postoperative hormonal drops, followed by gradual recovery. The total hormone score efficiently assessed pituitary function, simplifying complex hormonal dynamics.

Indexed as

AdenomaPituitary HormonesPituitary NeoplasmsAdultAgedFollicle Stimulating HormoneHumansHypopituitarismLuteinizing HormoneMaleMiddle AgedPerioperative PeriodRetrospective StudiesFollicle Stimulating HormoneLuteinizing HormonePituitary HormonesAdenohypophysial hormoneMale patients with pituitary adenomaPerioperative periodPituitary adenomaTransnasal sphenoidal surgery

Identifiers

PMID41586937

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