Evidence map›Paper›PMID 41586902›Full record

ArticlePediatric nephrology (Berlin, Germany)2026

Arterial stiffening in children with early chronic kidney disease is associated with blood pressure but not decline in kidney function: a longitudinal study from the HOT-KID cohort.

Louise Keehn, Phil J Chowienczyk, Rodney Gilbert, Andrew Lunn, Heather Maxwell, Henry Morgan, Mohan Shenoy, Rukshana Shroff, Pushpa Subramaniam, Jane Tizard and 2 more

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Article in Pediatric nephrology (Berlin, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Louise KeehnDepartment of Clinical Pharmacology, British Heart Foundation Centre, King's College London, London, UK.
Phil J ChowienczykDepartment of Clinical Pharmacology, British Heart Foundation Centre, King's College London, London, UK.
Rodney GilbertDepartment of Paediatric Nephrology, Southampton General Hospital, Southampton, UK.
Andrew LunnDepartment of Paediatric Nephrology, Nottingham University Hospital NHS Trust, Nottingham, UK.
Heather MaxwellDepartment of Paediatric Nephrology, Royal Hospital for Sick Children, Glasgow, UK.
Henry MorganDepartment of Paediatric Nephrology, Alder Hey Children's Hospital, Liverpool, UK.
Mohan ShenoyDepartment of Paediatric Nephrology, Royal Manchester Children's Hospital Manchester, Manchester, UK.
Rukshana ShroffDepartment of Paediatric Nephrology, UCL Great Ormond Street Hospital and Institute of Child Health, London, UK.
Pushpa SubramaniamDepartment of Paediatrics, St Georges Hospital, London, UK.
Jane TizardDepartment of Paediatric Nephrology, Bristol Royal Hospital for Children, Bristol, UK.
Yincent TseDepartment of Paediatric Nephrology, Great North Children's Hospital, Newcastle Upon Tyne, UK.
Manish D SinhaDepartment of Paediatric Nephrology, Evelina London Children's Hospital, Westminster Bridge Road, London, UK. manish.2.sinha@kcl.ac.uk.ORCID http://orcid.org/0000-0001-7593-1203

Funding

British Heart Foundation PG/11/90/28994
6 · The paper itself

Abstract

backgroundChildren with chronic kidney disease (CKD) are at risk of hypertension and increased arterial stiffness. We examined the roles of blood pressure (BP) and kidney function in development of arterial stiffening in children with early CKD, compared to healthy children.

methodsChildren who attended for two measurements (mean interval 3.1 ± 1.4 years) of carotid-femoral pulse wave velocity (PWV) as part of the HOT-KID study were included. Annual progression of PWV (PWV

resultsThere was no significant difference in PWV

conclusionsThese results indicate that there is no demonstrable difference in arterial stiffness between children with early CKD and those without. Renal function in early CKD does not appear to affect arterial stiffening, independent of the BP. The strong association between arterial stiffening and MAP suggests a need for careful BP control in children with CKD.

Indexed as

Blood PressureHypertensionKidneyRenal Insufficiency, ChronicVascular StiffnessAdolescentCarotid-Femoral Pulse Wave VelocityChildChild, PreschoolDisease ProgressionFemaleGlomerular Filtration RateHumansLongitudinal StudiesMalePulse Wave AnalysisArterial stiffeningBlood pressureChildrenCKDKidneyPulse wave velocity

Identifiers

PMID41586902
PMCPMC13197352

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.