ArticleEuropean radiology experimental2026
An endovascular porcine model of abdominal aortic aneurysm for interventional radiology research.
Article in European radiology experimental, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- A disintegrin and metalloproteinase with thrombospondin motifs 4-targeted molecular magnetic resonance imaging for early detection of extracellular matrix remodeling in a porcine model of abdominal aortic aneurysm.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic ResonanceArticle
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14 authors.
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Abstract
objectiveAbdominal aortic aneurysm (AAA) remains a life-threatening condition with few large-animal disease models. We aimed to develop a fully endovascular porcine AAA model for radiology research, reducing surgical trauma and improving reproducibility versus laparotomy-based models. MATERIALS AND
methodsFourteen female German Landrace swine (n = 14, 30-40 kg) underwent angiography-guided intervention. The animals' infrarenal aorta was dilated by ~30% via balloon catheter, then collagenase (6,000 IU), elastase (500 IU), and 25% calcium chloride (0.5 mL) were locally incubated to weaken the vessel wall. Eight animals were included in the study; group 1 (n = 4) was euthanized at 2 weeks, and group 2 (n = 4) at 4 weeks. Aortic diameter was measured weekly by ultrasound; ex vivo histology, immunofluorescence, and western blot assessed remodeling and inflammation.
resultsProgressive aneurysm expansion was observed, with diameters of 1.32 ± 0.08 cm (mean ± standard deviation) at 1 week post-intervention, 1.59 ± 0.06 cm at 2 weeks, 1.81 ± 0.10 cm at 3 weeks, and 1.94 ± 0.19 cm at 4 weeks (baseline: 0.74 ± 0.08 cm; p < 0.001). Experimental groups' macrophages increased (group 1, 15.12 ± 3.88%; group 2, 16.65 ± 5.27%) compared to control (0.66 ± 0.27%, p = 0.012 and p = 0.021, respectively). Vascular smooth muscle cells were reduced across interventional groups (45.97 ± 17.26% versus control 80.94 ± 14.26%, p = 0.005).
conclusionsThis porcine AAA model replicates human disease features with a fully endovascular workflow, offering a valuable platform for evaluation of novel imaging techniques and interventional therapies. RELEVANCE STATEMENT: This study presents a fully endovascular porcine model of abdominal aortic aneurysm for translational research in interventional radiology and imaging. By enabling aneurysm induction entirely through catheter-based techniques, the model could provide a clinically relevant platform for future evaluation of novel endovascular devices and intraluminal therapeutics. KEY POINTS: This study established a fully endovascular, translational porcine model of abdominal aortic aneurysm. The model exhibited a significant mean aneurysmal dilation of about 161% at 4 weeks and 107% at 2 weeks. Serial ultrasound confirmed consistent aneurysm expansion and reproducible growth patterns in surviving animals. Ex vivo analyses demonstrated inflammation and extracellular-matrix damage, mirroring key features of human abdominal aortic aneurysm pathology. This fully catheter-based workflow provides a practical preclinical platform for evaluating imaging techniques and endovascular therapies.
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