ArticleClinical research in cardiology : official journal of the German Cardiac Society2026
Temporal trends and projections in Hypertension with Substance Use-related mortality, 1999-2035: Insights from the CDC WONDER database.
Article in Clinical research in cardiology : official journal of the German Cardiac Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed.
- Temporal trends and forecasted mortality involving lung cancer with co-listed hypertension in U.S. adults, 2000-2035.Cardio-oncology (London, England) · 2026Article
- Unveiling temporal trends and disparities in mortality with co-listed coronary artery disease and cancer, 1999-2024: insights from the CDC WONDER multiple cause of death database.Cardio-oncology (London, England) · 2026Article
- Temporal Trends and Forecasted Cardiac Arrest and Hypertension-Related Mortality in U.S. Adults, 2000-2035: A Nationwide CDC WONDER Multiple Cause-of-Death Study.Journal of epidemiology and global health · 2026Article
- Temporal Trends and Future Projections of P ulmonary Embolism and Top Contributing Causes of death in the United States, 1968-2040: insights from the CDC WONDER database.Journal of thrombosis and thrombolysis · 2026Article
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Abstract
backgroundTo examine national trends and forecast future mortality involving hypertension and substance use among United States (US) adults from 1999 to 2035. Hypertension contributes substantially to mortality in the US, particularly among populations with substance use. The interplay between hypertension and substance use varies by gender, race, age, and geography. Hypertension contributes substantially to mortality across the US, particularly among populations with substance use. The interplay between hypertension and SU varies by gender, race, age, and geography.
methodsUsing the CDC WONDER Multiple Cause-of-Death database, we conducted a retrospective analysis of hypertension with substance use mortality from 1999-2024 among adults aged ≥ 25 years. Age-Adjusted Mortality Rates (AAMRs) were calculated, and Joinpoint regression estimated annual and average annual percentage changes (APC, AAPC) with 95% confidence intervals. Auto-ARIMA and Prophet time-series models in R (v4.5.0) projected AAMRs through 2035, evaluated by root mean squared error (RMSE).
resultsFrom 1999 to 2024, a total of 405,692 deaths involving hypertension and substance use occurred in the US. AAMR increased from 1.32 to 13.9 (AAPC 9.38; p < 0.001). Men had higher AAMRs than women (10.38 vs 3.06). NH American Indian/Alaska Native adults had the highest mean AAMR (17.89), followed by NH Black (11.59), White (6.37), and Hispanic (4.94) adults. Middle-aged adults (45-64) had the greatest burden (10.95). AAMRs ranged from 2.91 in Alabama to 15.03 in the District of Columbia, highest in the West (8.05) and South (6.76). Urban areas slightly exceeded rural (5.31 vs 5.10). Alcohol accounted for 49.3% of deaths, followed by intentional overdose (16.4%) and cocaine (12.7%). Projections to 2035 indicate continued rises, particularly among men, NH American Indian/Alaska Native individuals, middle-aged adults, and in the West and South.
conclusionHypertension with substance use-related mortality has risen sharply, with persistent demographic and regional disparities warranting targeted prevention strategies.
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