Evidence map›Paper›PMID 41586833›Full record

ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2026

Paternal age is associated with offspring bone health-but not soft tissue composition or fracture: the Vitamin D in Pregnancy Study.

Mia A Percival, Kara B Anderson, Julie A Pasco, Marc Sim, Sarah M Hosking, John D Wark, Natalie K Hyde

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Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Mia A PercivalIMPACT, The Institute for Mental and Physical Health and Clinical Translation, Deakin University, PO Box 281, Geelong, VIC, 3220, Australia. mia.percival@research.deakin.edu.au.
Kara B AndersonIMPACT, The Institute for Mental and Physical Health and Clinical Translation, Deakin University, PO Box 281, Geelong, VIC, 3220, Australia.
Julie A PascoIMPACT, The Institute for Mental and Physical Health and Clinical Translation, Deakin University, PO Box 281, Geelong, VIC, 3220, Australia.
Marc SimSchool of Medical and Health Sciences, Nutrition and Health Innovation Research Institute, Edith Cowan University, Joondalup, WA, 6027, Australia.
Sarah M HoskingIMPACT, The Institute for Mental and Physical Health and Clinical Translation, Deakin University, PO Box 281, Geelong, VIC, 3220, Australia.
John D WarkDepartment of Medicine, Royal Melbourne Hospital, University of Melbourne, Parkville, VIC, 3050, Australia.
Natalie K HydeIMPACT, The Institute for Mental and Physical Health and Clinical Translation, Deakin University, PO Box 281, Geelong, VIC, 3220, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Emerging evidence suggests that paternal health may be associated with offspring later life heath. In this study, advanced paternal age at childbirth was associated with poorer offspring bone mineral density and content at age 11 years. These findings suggest that paternal age may impact childhood musculoskeletal development, warranting further investigation.

introductionMaternal health during pregnancy is known to impact offspring's later life health. However, emerging evidence suggests that paternal factors may also be important. Advanced paternal age is associated with poorer offspring outcomes, yet few studies assess musculoskeletal outcomes. This study investigated the association between paternal age at childbirth and musculoskeletal outcomes of offspring at ages 11 and 16 years.

methodsData were from 402 mother-child pairs in the Vitamin D in Pregnancy study in southeastern Australia. Paternal date of birth was available for 173 fathers. Offspring lean, fat, and bone mass (spine and total body less head) were measured using dual-energy X-ray absorptiometry at age 11 years, and radiologically confirmed fractures were ascertained from birth (2002-2004) until July 19, 2019. Multivariable linear regression models were used to assess associations between paternal age and offspring bone and soft tissue composition outcomes, while multivariable Cox proportional hazards models were used to evaluate associations with offspring fracture occurrence.

resultsIn total, 89 father-child pairs had data for bone and soft tissue composition analysis and 173 for fracture outcomes. In adjusted models, paternal age was associated with lower offspring total body less head bone mineral density (β - 0.002 g/cm

conclusionAdvanced paternal age may affect offspring musculoskeletal outcomes in childhood. This warrants further investigation in larger cohorts.

Indexed as

Body CompositionBone DensityFractures, BoneOsteoporotic FracturesPaternal AgeAbsorptiometry, PhotonAdolescentAdultAnthropometryChildFemaleHumansMalePregnancyPrenatal Exposure Delayed EffectsBone healthFracturePaternal agePaternal origins

Identifiers

PMID41586833
PMCPMC13083492

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.