ArticleJMIR research protocols2026
Determinants Associated With Pesticide Exposure in Patients With Head and Neck Cancer: Protocol for a Systematic Review.
Article in JMIR research protocols, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Currently, head and neck cancer (HNC) associated with pesticide exposure represents a global public health concern. However, there is no consensus regarding the specific determinants involved in this association. Moreover, there is a lack of scientific evidence to support the development of systematic reviews on this topic. Objective: This study aims to synthesize the methodology for conducting a systematic review to explore the current scientific evidence on the determinants of HNC associated with pesticides. Methods: The review will follow the PRISMA-P (Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols) guidelines to ensure methodological rigor. The protocol includes detailed steps for constructing a robust search strategy using relevant databases such as PubMed, Embase, Scopus, Web of Science, CINAHL, LILACS, and AGRICOLA. Keywords and Medical Subject Headings terms related to "pesticides," "exposure," "head and neck neoplasms," and related concepts will be used to capture the most relevant studies. Eligibility criteria will be clearly defined, including study design (eg, cohort, case-control, and cross-sectional), population characteristics, exposure assessment, and cancer outcomes. Studies published in any language that involve human participants will be included. The studies will be screened in 2 phases: first by title and abstract and then by full-text review. Two independent reviewers will assess the quality of each study and extract key data, such as exposure levels, cancer subtypes, and effect sizes. Any disagreements will be resolved through discussion or by a third reviewer. Results: This systematic review was initiated in February 2025 after protocol registration. The literature search and review process is ongoing at the time of submission of this paper. Data extraction and quality assessment have not yet been completed. Final results of the review, including a synthesis of determinants associated with pesticide exposure in patients with HNC, are expected to be completed and submitted for publication in June 2026. Conclusions: The necessary steps to conduct a systematic review must be concise and publicly available to ensure replicability within the scientific community.
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Registered trials
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