ArticleEndocrine connections2026
The role of vitamin D in pregnancy outcomes in gestational diabetes: a randomized controlled trial.
Article in Endocrine connections, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 authors.
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Abstract
Background: This study evaluated the effects of vitamin D supplementation on oxidative stress, inflammation, and pregnancy outcomes in women with gestational diabetes mellitus (GDM). Methods: In a randomized, double-blind, placebo-controlled trial, 229 women with GDM were assigned to receive 200 IU of vitamin D twice daily or a placebo for 6 weeks alongside standard care. Biomarkers and pregnancy outcomes were assessed. Results: Vitamin D supplementation significantly increased serum 25(OH)D and calcium levels, improved oxidative stress markers (increased GSH and decreased MDA), and reduced hs-CRP compared to placebo. The vitamin D group had a lower neonatal birth weight and a reduced incidence of macrosomia. No significant differences were found in fasting glucose changes or most other obstetric outcomes. Conclusion: A 6-week vitamin D supplementation in women with GDM improved vitamin D status, ameliorated oxidative stress and inflammation, and was associated with reduced neonatal birth weight and macrosomia, without significantly affecting glycemic control.
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