Observational studyCritical care explorations2026
Effect of Neurologic Conditions on Delirium Duration and Time to ICU Discharge.
Observational study in Critical care explorations, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed, 1 synthesis or guideline pooled it.
- Prevalence of pediatric delirium among critically ill children: a meta-analysis of observational studies.Frontiers in pediatrics · 2026Pooled it
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
importanceDelirium is prevalent and associated with poorer clinical outcomes in critically ill children.
objectivesWe sought to determine whether presence of baseline developmental delay (DD) or a primary admission diagnosis of an acute neurologic condition (ANC) was associated with longer delirium duration and/or time to ICU discharge, and whether delirium acts as a mediator among observed outcome associations. DESIGN, SETTING, AND
participantsPost hoc analysis of a prospective, observational study in patients 6 months to 5 years old admitted to a tertiary PICU regardless of admission diagnosis. MAIN OUTCOMES AND MEASURES: Patients assessed daily for delirium using the Pediatric Confusion Assessment Method for the ICU series (PEDs CAM-ICU). Baseline demographics and in-hospital outcomes obtained.
resultsOf 282 patients, 79 had baseline DD and 54 were admitted with an ANC. Delirium prevalence among patients with DD was 53% and 43% in those with an ANC. DD was associated with significantly longer delirium duration (p = 0.008), with a meaningful association between ANC and delirium duration (p = 0.056). DD was significantly associated with a lower likelihood of ICU discharge (hazard ratio, HR, 0.76 [95% CI, 0.54-0.95]), with delirium partially mediating this relationship. Patients with ANC diagnoses trended toward a relevant association with lower likelihood of ICU discharge (HR 0.73 [0.53-1.00]) with partial delirium mediation. CONCLUSIONS AND RELEVANCE: Baseline DD among critically ill infants and children is linked to longer delirium duration and lower likelihood of ICU discharge. An innovative finding is that delirium mediates this relationship. Although ANCs were loosely correlated with both prolonged delirium duration and decreased likelihood of ICU discharge, the true impact of delirium on these patients warrants further investigation. Finally, a focus on how to mitigate the impact of DD (predisposing risk factor) on ICU delirium and outcomes in critically ill infants and children is paramount.
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