ArticleThe MAK collection for occupational health and safety2025
Trichlorobenzene (all isomers): MAK Value Documentation, addendum - Translation of the German version from 2022.
Article in The MAK collection for occupational health and safety, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The German Senate Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area (MAK Commission) has re-evaluated the occupational exposure limit value (maximum concentration at the workplace, MAK value) of trichlorobenzene isomers (1,2,3-trichlorobenzene [87-61-6], 1,2,4-trichlorobenzene [120-82-1] and 1,3,5-trichlorobenzene [108-70-3]) considering all toxicological end points. Relevant studies were identified from a literature search and also unpublished study reports were used. The critical effects of the trichlorobenzenes are adverse effects on the livers of mice and rats and on the kidneys of rats. These effects were more pronounced after exposure to 1,2,4-trichlorobenzene with the rat being the most sensitive species. However, as the isomers all have a similar primary toxicological mode of action and follow similar metabolic pathways, they have been evaluated together. After exposure to 1,2,4-trichlorobenzene, liver toxicity was manifest in rats and mice as increased liver weights and histological changes in the liver were preceded by an induction of metabolic enzymes. The most sensitive end point, a disruption of porphyrin biosynthesis, was observed in a 90-day inhalation study in rats with a NOAEC of 3 ml/m
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