Evidence map›Paper›PMID 41586693›Full record

ArticleLab on a chip2026

STARTER: a stand-alone reconfigurable and translational organ-on-chip platform based on modularity and open design principles.

Aniruddha Paul, Eric R Safai, Laura E de Heus, Anke R Vollertsen, Kevin Weijgertse, Bjorn de Wagenaar, Hossein E Amirabadi, Evita van de Steeg, Mathieu Odijk, Andries D van der Meer and 1 more

Abstract read
In one paragraph

Article in Lab on a chip, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Aniruddha PaulBIOS Lab on Chip Group, Mesa+ Institute of Nanotechnology, University of Twente, The Netherlands.ORCID 0009-0000-2076-1307
Eric R SafaiDepartment of Bioengineering Technologies, University of Twente, The Netherlands.ORCID 0000-0002-9244-8915
Laura E de HeusDepartment of Bioengineering Technologies, University of Twente, The Netherlands.ORCID 0000-0002-6992-221X
Anke R VollertsenDepartment of Bioengineering Technologies, University of Twente, The Netherlands.
Kevin WeijgertseNetherlands Organization for Applied Scientific Research (TNO), Leiden, The Netherlands.
Bjorn de WagenaarNetherlands Organization for Applied Scientific Research (TNO), Leiden, The Netherlands.
Hossein E AmirabadiAZAR Innovations, Utrecht, The Netherlands.
Evita van de SteegNetherlands Organization for Applied Scientific Research (TNO), Leiden, The Netherlands.
Mathieu OdijkIDS - Integrated Devices and Systems Group, MESA+ Institute of Nanotechnology, University of Twente, The Netherlands.ORCID 0000-0002-4467-9604
Andries D van der MeerDepartment of Bioengineering Technologies, University of Twente, The Netherlands.ORCID 0000-0002-8761-4077
Joshua Loessberg-ZahlBIOS Lab on Chip Group, Mesa+ Institute of Nanotechnology, University of Twente, The Netherlands.ORCID 0000-0002-4491-5179

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Organ-on-chips (OoC) have the potential to revolutionize drug testing. However, the fragmented landscape of existing OoC systems leads to wasted resources and collaboration barriers, slowing broader adoption. To unite the ecosystem, there is an urgent need for generic OoC platforms based on interoperability and modularity. Technology platforms based on open designs would enable seamless integration of diverse OoC models and components, facilitating translation. Our study introduces a modular microfluidic platform that integrates swappable modules for pumping, sensing, and OoCs, all within the ANSI/SLAS microplate footprint. Sub-components operate as microfluidic building blocks (MFBBs) and can interface with the demonstrated fluidic circuit board (FCB) universally as long as the designs adhere to ISO standards. The platform architecture allows tube-less inter-module interactions

Indexed as

Lab-On-A-Chip DevicesMicrofluidic Analytical TechniquesAnimalsEquipment DesignHumansMicrophysiological Systems

Identifiers

PMID41586693
PMCPMC12834090

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.