YhcB mediates growth-phase control of fatty acid biosynthesis through regulation of acetyl-CoA carboxylase.

Abstract read

In one paragraph

Article in mBio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

Impaired envelope integrity in the absence of SanA is linked to increased lipid II availability and an imbalance of septal peptidoglycan synthesis.mBio · 2026
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Hannah M StanleyDepartment of Microbiology, College of Art and Sciences, University of Georgia, Athens, Georgia, USA.

M Stephen TrentDepartment of Microbiology, College of Art and Sciences, University of Georgia, Athens, Georgia, USA.ORCID 0000-0001-6134-1800

Funding

The Cell Envelope of the Multi-Drug Resistant Pathogen Acinetobacter baumanniiR01AI150098 · NIAID · UNIVERSITY OF GEORGIA · PI Michael Stephen Trent · 2020 to 2026

$3.9M

Synthesis and transport of outer membrane components across the Gram-negative cell envelopeR01AI176776 · NIAID · UNIVERSITY OF GEORGIA · PI Michael Stephen Trent · 2023 to 2026

$2.5M

The role of cardiolipin in the biogenesis of the Gram-negative bacterial cell envelopeR01AI174416 · NIAID · UNIVERSITY OF GEORGIA · PI Michael Stephen Trent · 2023 to 2026

$2.4M

Life Sciences Division, Army Research Office W911NF2010195National Science Foundation GRF 2236869NIAID NIH HHS R01 AI150098NIAID NIH HHS R01 AI174416NIAID NIH HHS R01 AI176776

6 · The paper itself

Abstract

Cell envelope biogenesis is an essential process that requires coordination of many complex pathways, including the synthesis of fatty acids, lipopolysaccharides, and glycerophospholipids. Loss of IMPORTANCE: The gram-negative cell envelope is synthesized through coordination of many complex pathways, requiring adaptable regulation at the DNA, RNA, and protein levels. Fatty acid biosynthesis, a highly energy-demanding process, is essential for cell viability and a promising target for antimicrobial design. We identify two previously unrecognized mechanisms that regulate this pathway: proteolytic turnover and YhcB-mediated sequestration of a protein dedicated to the initiation of fatty acid biosynthesis. These findings reveal new layers of control over membrane biogenesis that could be exploited for antimicrobial strategies.

Indexed as

Acetyl-CoA CarboxylaseEscherichia coliEscherichia coli ProteinsFatty AcidsGene Expression Regulation, BacterialProteolysisAcetyl-CoA CarboxylaseEscherichia coli ProteinsFatty AcidsAccAACC complexacetyl-CoA carboxylasecell envelopeFatty acid biosynthesismembrane biogenesisYhcB

Identifiers

PMID41586617

DOI10.1128/mbio.03681-25

PMCPMC12977641

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.