ArticlemSystems2026
Group A streptococcal PerR coordinates iron and zinc homeostasis through Dpr, aiding in bacterial fitness during endothelial cell infection.
Marcia Shu-Wei Su, Chia-Jung Lee, Yi-Lin Cheng, Wei-Jiun Tsai, Chuan Chiang-Ni, Kai-Yu Wang, Yi-Chun Hsieh, Chen-Chieh Liao, Jiunn-Jong Wu
Abstract read
In one paragraphArticle in mSystems, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
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4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
9 authors.
Marcia Shu-Wei SuDepartment of Medical Laboratory Science and Biotechnology, College of Medical and Health Sciences, Asia University, Taichung, Taiwan.ORCID 0000-0002-5054-7800 Chia-Jung LeeDepartment of Biotechnology and Laboratory Science in Medicine, College of Biomedical Science and Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Yi-Lin ChengInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Wei-Jiun TsaiInstitute of Basic Medical Sciences, College of Medicine, National Cheng Kung University, Tainan, Taiwan.
Chuan Chiang-NiDepartment of Microbiology and Immunology, Chang Gung University, Taoyuan, Taiwan.
Kai-Yu WangDepartment of Life Sciences, College of Bioscience and Biotechnology, National Cheng Kung University, Tainan, Taiwan.
Yi-Chun HsiehDepartment of Medical Laboratory Science and Biotechnology, College of Medical and Health Sciences, Asia University, Taichung, Taiwan.
Chen-Chieh LiaoDepartment of Biotechnology and Laboratory Science in Medicine, College of Biomedical Science and Engineering, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Jiunn-Jong WuDepartment of Medical Laboratory Science and Biotechnology, College of Medical and Health Sciences, Asia University, Taichung, Taiwan.ORCID 0000-0002-5080-9778 Funding
National Science and Technology Council 111-2320-B-468-005, 112-2320-B-468-005, 113-2320-B-468-001, 113-2320-B-468-001-MY3, 111-2811-B-468-001, 112-2811-B-468-001, 113-2811-B-468-002, 114-2811-B-468-001
6 · The paper itselfAbstract
IMPORTANCE: Our study combines dual RNA-seq analysis, an endothelial cell infection model, computational predictions, and phenotypic characterization to discover the impact of group A
Indexed as
Bacterial ProteinsEndothelial CellsIronRepressor ProteinsStreptococcal InfectionsStreptococcus pyogenesZincGene Expression Regulation, BacterialHomeostasisHumansOxidative StressBacterial ProteinsIronperoxide repressor proteinsRepressor ProteinsZincDprgroup A Streptococcushuman endothelial cellsPerRROSzinc homeostasis
Identifiers
PMID41586523
PMCPMC12911349
What OpenQuestion holds
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LicenceCC BY
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