ArticleIEEE open journal of ultrasonics, ferroelectrics, and frequency control2025
Surface Compression Alters in Vivo VisR Stiffness, Viscosity, and Anisotropy Measurements in Human Breast.
Article in IEEE open journal of ultrasonics, ferroelectrics, and frequency control, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Viscoelastic response (VisR) ultrasound has been developed by our group to interrogate tissue stiffness and viscosity. VisR has several potential advantages for breast cancer diagnostic imaging such being non-invasive and low-cost. Because ultrasound can penetrate dense breasts more effectively than mammograms, it may improve the detection of malignant masses in women with dense breasts. VisR-based estimates of stiffness, viscosity, and anisotropy have been shown in our preliminary studies to discriminate malignant and benign breast lesions. However, a potential limitation of VisR could be dependence on tissue pre-loading from applied surface compression by the practitioner. We conducted an IRB-approved clinical study of 20 women with no known breast pathologies to assess the impact of compression on VisR measurements of peak displacement (PD), relative elasticity (RE), relative viscosity (RV), and degree of anisotropy (DoA). Participants were between the ages of 30-90, and 10/20 had mammographically dense breasts. We found that surface compression significantly affected measurements of PD, RE, and RV in breast tissue,
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