Evidence map›Paper›PMID 41586361›Full record

ArticleFrontiers in microbiology2025

N6-adenosine-methyltransferase MTA70-like participates antiviral responses in

Haijuan Wang, Tianyi Zhang, Jiaxin Xu, Zhenqi Sun, Zhaoran Wu, Baolong Zhang, Qianqian Zhao, Xiangdong Yang, Mingmin Zhao

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In one paragraph

Article in Frontiers in microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Haijuan WangCollege of Horticulture and Plant Protection, Inner Mongolia Agricultural University, Hohhot, China.
Tianyi ZhangCollege of Horticulture and Plant Protection, Inner Mongolia Agricultural University, Hohhot, China.
Jiaxin XuCollege of Horticulture and Plant Protection, Inner Mongolia Agricultural University, Hohhot, China.
Zhenqi SunCollege of Horticulture and Plant Protection, Inner Mongolia Agricultural University, Hohhot, China.
Zhaoran WuCollege of Horticulture and Plant Protection, Inner Mongolia Agricultural University, Hohhot, China.
Baolong ZhangCollege of Horticulture and Plant Protection, Inner Mongolia Agricultural University, Hohhot, China.
Qianqian ZhaoJilin Academy of Agricultural Sciences, Changchun, China.
Xiangdong YangJilin Academy of Agricultural Sciences, Changchun, China.
Mingmin ZhaoCollege of Horticulture and Plant Protection, Inner Mongolia Agricultural University, Hohhot, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Previous studies have shown that m6A methylation has a certain regulatory role in the replication of human viruses and plant viruses. Particularly, the m6A methylation in the host endogenous gene significantly decreased after the infection of potato virus Y (PVY). Methods: Here, we cloned and characterized N6-adenosine-methyltransferase MTA70-like (ToMTA70) from tomato. The ToMTA70 was constructed into the pMDC32 binary vector. To create the ToMTA70 mutant, sequence of the MTA70 superfamily domain (493-653) with PDS and GUS sequences, respectively. The effect of the ToMTA70 on viral accumulation was studied using an Agrobacterium-mediated transient expression assay. Results: A conserved MT-A70 superfamily domain in ToMTA70 was identified by encoding sequence and structural analyses, which indicating ToMTA70 might involve in m6A methylation. The transient expression of ToMTA70 inhibited viral accumulation of PVY. When the conserved domain of MTA70 super family was replaced by PDS and GUS (ToMTA70-PDS or ToMTA70-GUS), the PVY infection was increased in plants comparing with the control. However, transiently expression of ToMTA70 did not show any influence on TVMV and TMV infection. Discussion: This suggests that ToMTA70 participate in plant antiviral responses of PVY, which can be applied for engineering the anti-viral strategy.

Indexed as

antiviral responsesN6-adenosine-methyltransferase MTA70-likeNicotiana benthamianapotato virus YTomatoToMTA70

Identifiers

PMID41586361
PMCPMC12826071

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.