Evidence map›Paper›PMID 41586345›Full record

ArticleGastro hep advances2026

Contrast-Enhanced Ultrasound and Somatostatin Receptor Scintigraphy Unveil an Occult Neuroendocrine Tumor With Carcinoid Syndrome and Presumed Small Intestinal Origin - A Case Report.

Tairyu Sato, Akira Nishio, Tadashi Kegasawa, Kazuna Hazu, Chihiro Tarumi, Koki Yamada, Yuki Nishiura, Kumi Higashihara, Shogo Nagahama, Takayuki Matsumae and 12 more

Abstract readCase Reports
In one paragraph

Article in Gastro hep advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Tairyu SatoDepartment of Gastroenterology and Hepatology, Japan Community Healthcare Organization, Osaka Hospital, Osaka, Japan.
Akira NishioDepartment of Gastroenterology and Hepatology, Japan Community Healthcare Organization, Osaka Hospital, Osaka, Japan.
Tadashi KegasawaDepartment of Gastroenterology and Hepatology, Japan Community Healthcare Organization, Osaka Hospital, Osaka, Japan.
Kazuna HazuDepartment of Gastroenterology and Hepatology, Japan Community Healthcare Organization, Osaka Hospital, Osaka, Japan.
Chihiro TarumiDepartment of Gastroenterology and Hepatology, Japan Community Healthcare Organization, Osaka Hospital, Osaka, Japan.
Koki YamadaDepartment of Gastroenterology and Hepatology, Japan Community Healthcare Organization, Osaka Hospital, Osaka, Japan.
Yuki NishiuraDepartment of Gastroenterology and Hepatology, Japan Community Healthcare Organization, Osaka Hospital, Osaka, Japan.
Kumi HigashiharaDepartment of Gastroenterology and Hepatology, Japan Community Healthcare Organization, Osaka Hospital, Osaka, Japan.
Shogo NagahamaDepartment of Gastroenterology and Hepatology, Japan Community Healthcare Organization, Osaka Hospital, Osaka, Japan.
Takayuki MatsumaeDepartment of Gastroenterology and Hepatology, Japan Community Healthcare Organization, Osaka Hospital, Osaka, Japan.
Yuki TokudaDepartment of Gastroenterology and Hepatology, Japan Community Healthcare Organization, Osaka Hospital, Osaka, Japan.
Aya IshimiDepartment of Gastroenterology and Hepatology, Japan Community Healthcare Organization, Osaka Hospital, Osaka, Japan.
Satoshi HiyamaDepartment of Gastroenterology and Hepatology, Japan Community Healthcare Organization, Osaka Hospital, Osaka, Japan.
Masafumi OgataDepartment of Pathology, Japan Community Healthcare Organization, Osaka Hospital, Osaka, Japan.
Chiaki NakaiDepartment of Pathology, Japan Community Healthcare Organization, Osaka Hospital, Osaka, Japan.
Keitaro MasukoDepartment of Radiology, The University of Osaka Graduate School of Medicine, Suita, Japan.
Katsumi YamamotoDepartment of Gastroenterology and Hepatology, Japan Community Healthcare Organization, Osaka Hospital, Osaka, Japan.
Nobuyuki TatsumiDepartment of Gastroenterology and Hepatology, Japan Community Healthcare Organization, Osaka Hospital, Osaka, Japan.
Yasuyuki YoshidaDepartment of Pathology, Japan Community Healthcare Organization, Osaka Hospital, Osaka, Japan.
Kayako IsohashiDepartment of Radiology, The University of Osaka Graduate School of Medicine, Suita, Japan.
Yoshito HayashiDepartment of Gastroenterology and Hepatology, The University of Osaka Graduate School of Medicine, Suita, Japan.
Akira KanekoDepartment of Gastroenterology and Hepatology, Japan Community Healthcare Organization, Osaka Hospital, Osaka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 68-year-old man with postprandial flushing and palpitations was referred for multiple hepatic lesions. Computed tomography showed hypoattenuating metastases without a detectable primary, whereas contrast-enhanced ultrasound revealed arterial hyperenhancement and Kupffer-phase defects, indicating hypervascularity typical of neuroendocrine tumors (NETs). Urinary 5-hydroxyindoleacetic acid elevation, together with liver biopsy findings, confirmed a well-differentiated NET (grade 2), presenting with carcinoid syndrome. Somatostatin receptor scintigraphy demonstrated diffuse hepatic uptake and a mesenteric focus, suggesting a small intestine origin. Lanreotide was initiated, achieving partial symptom improvement and radiologic stability. This case highlights contrast-enhanced ultrasound for demonstrating hypervascularity and somatostatin receptor scintigraphy for localizing an occult origin in NET.

Indexed as

Carcinoid SyndromeContrast-Enhanced UltrasoundHepatic Metastasesneuroendocrine TumorPeptide Receptor Radionuclide TherapySomatostatin Receptor Imaging

Identifiers

PMID41586345
PMCPMC12828494

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.