ReviewFrontiers in cellular and infection microbiology2025
Bidirectional interplay between periodontal disease and carotid artery disease: a comprehensive holistic review.
Review in Frontiers in cellular and infection microbiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
2 citing papers in PubMed.
- Periodontal disease and cardiovascular events: mechanisms, biomarkers, and clinical translation.NPJ cardiovascular health · 2026Review
- The relationship of apical periodontitis with chronic diseases and smoking habits: an umbrella review.Odontology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Periodontal disease and atherosclerosis are two highly prevalent chronic inflammatory conditions that may be pathophysiologically linked. Objective: This review aims to critically assess the current literature regarding the potential causal relationship between periodontitis, the atherosclerotic process, and particularly the progression of carotid artery disease. Although numerous observational studies support an association between periodontitis and cardiovascular diseases, the evidence remains inconclusive in demonstrating periodontal disease as an independent risk factor in the development of carotid atherosclerotic plaques. Conclusion: While there is substantial biological plausibility for a link between periodontal disease and atherosclerosis, current evidence is insufficient to confirm a direct causal role, particularly in carotid artery disease. Further longitudinal and interventional studies are necessary to elucidate the mechanisms involved and determine whether periodontal treatment may contribute to cardiovascular risk reduction. The potential public health implications of these findings highlight the necessity for comprehensive preventive and therapeutic oral health interventions aimed at reducing associated systemic risks.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.