ArticleNPJ dementia2026
Genetic contributions to Alzheimer's disease and frontotemporal dementia in admixed Latin American populations.
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Article in NPJ dementia, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13citing papers in PubMed
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Who cites it
13 citing papers in PubMed.
- Beyond Targeted Gene Panels: Whole-Exome Sequencing as a Strategic Platform for Precision Therapeutics in Alzheimer's Disease.Life (Basel, Switzerland) · 2026Review
- Genetic-exposome interactions and aging clocks in dementia: the ReDLat2 initiative.Nature medicine · 2026Article
- Phenotypic diversity of frontotemporal lobar degeneration in two novel GRN variants from Colombia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- The Versatile Roles of Exosomes in Neurodegenerative Disorders: From Pathological Mechanism and Diagnostic Biomarkers to Therapeutic Application.Drug design, development and therapy · 2026Review
- Advancing global dementia research through equity and inclusion.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Computational whole-body-exposome models for global precision brain health.Nature communications · 2025Article
- Brain banks in Latin America: Infrastructure for diagnosis, research, and scientific equity in Mexico and the Caribbean.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- From Better Diagnostics to Earlier Treatment: The Rapidly Evolving Alzheimer's Disease Landscape.Medicina (Kaunas, Lithuania) · 2025Review
- Insights into pathophysiology, biomarkers, and therapeutics in tauopathies: Proceedings of the Tau2024 Global Conference.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Heterozygous TREM2 (p.W44X) and PSEN1 (p.A431T) mutations in two Peruvian families with familial Alzheimer's disease: expanding the genetic landscape in underrepresented populations.Frontiers in neuroscience · 2025Article
- Non-coding variation in dementias: mechanisms, insights, and challenges.NPJ dementia · 2025Review
- Case of early onset Alzheimer's disease associated with a novel PSEN1 variant identified in Colombia.NPJ dementia · 2025Article
- Time to diagnosis in FTLD-associated syndromes in Latin America.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
42 authors.
Juliana Acosta-Uribe *Grupo de Neurociencias de Antioquia (GNA), Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
Stefanie D Piña-Escudero *Global Brain Health Institute (GBHI), Department of Neurology, University of California San Francisco, San Francisco, USA CA.
J Nicholas CochranHudsonAlpha Institute for Biotechnology, Huntsville, USA AL.
Jared W TaylorHudsonAlpha Institute for Biotechnology, Huntsville, USA AL.
P Alejandra CastruitaMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, USA CA.
Caroline JonsonMemory and Aging Center, Department of Neurology, Weill Institute for Neurosciences, University of California San Francisco, San Francisco, USA CA.
Erin A BarinagaHudsonAlpha Institute for Biotechnology, Huntsville, USA AL.
Kevin RobertsHudsonAlpha Institute for Biotechnology, Huntsville, USA AL.
Alexandra R LevineNeuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California Santa Barbara, Santa Barbara, USA CA.
Dawwod S GeorgeNeuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California Santa Barbara, Santa Barbara, USA CA.
José Alberto Ávila-FunesInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.
María I BehrensDepartamento de Neurología y Psiquiatría, Clínica Alemana-Universidad del Desarrollo, Santiago, Chile.
Martín A BrunoInstituto de Ciencias Biomédicas (ICBM), Facultad de Ciencias Médicas, Universidad Católica de Cuyo, San Juan, Argentina.
Luis I BruscoAsociación Alzheimer Argentina (ALZAR), Buenos Aires, Argentina.
Nilton CustodioInstituto Peruano de Neurociencias, Lima, Perú.
Claudia Durán-AniotzLatin American Institute for Brain Health (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.
Francisco LoperaGrupo de Neurociencias de Antioquia (GNA), Facultad de Medicina, Universidad de Antioquia, Medellín, Colombia.
Diana L MatallanaInstituto de Envejecimiento, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá, Colombia.
Andrea SlachevskyDepartamento de Neurología y Psiquiatría, Clínica Alemana-Universidad del Desarrollo, Santiago, Chile.
Leonel T TakadaHospital das Clínicas, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brasil.
Lina M Zapata-RestrepoFacultad de Ciencias de la Salud, Universidad Icesi, Cali, Colombia.
Dafne E Durón-ReyesInstituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Ciudad de México, México.
Elisa de Paula França ResendeGlobal Brain Health Institute (GBHI), Department of Neurology, University of California San Francisco, San Francisco, USA CA.
Luisa F GómezInstituto de genética humana, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá, Colombia.
Nancy GelvezInstituto de genética humana, Facultad de Medicina, Pontificia Universidad Javeriana, Bogotá, Colombia.
M Beatriz BistueInstituto de Ciencias Biomédicas (ICBM), Facultad de Ciencias Médicas, Universidad Católica de Cuyo, San Juan, Argentina.
Maria E GodoyLatin American Institute for Brain Health (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.
Marcelo A MaitoLatin American Institute for Brain Health (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.
Shireen JavandelGlobal Brain Health Institute (GBHI), Department of Neurology, University of California San Francisco, San Francisco, USA CA.
Bruce L MillerGlobal Brain Health Institute (GBHI), Department of Neurology, University of California San Francisco, San Francisco, USA CA.
Mike A NallsDataTecnica LLC, Washington, USA DC.
Hampton LeonardDataTecnica LLC, Washington, USA DC.
Dan VitaleDataTecnica LLC, Washington, USA DC.
Sara Bandres-CigaCenter for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, USA MD.
Mathew J KoretskyDataTecnica LLC, Washington, USA DC.
Andrew B SingletonCenter for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, USA MD.
Caroline B PantazisCenter for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, USA MD.
Victor ValcourGlobal Brain Health Institute (GBHI), Department of Neurology, University of California San Francisco, San Francisco, USA CA.
Agustin IbañezLatin American Institute for Brain Health (BrainLat), Universidad Adolfo Ibanez, Santiago, Chile.
Kenneth S KosikNeuroscience Research Institute and Department of Molecular, Cellular and Developmental Biology, University of California Santa Barbara, Santa Barbara, USA CA.
Jennifer S YokoyamaGlobal Brain Health Institute (GBHI), Department of Neurology, University of California San Francisco, San Francisco, USA CA.
Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat)*
Funding
STRIDESOT2OD027852 · OD · FOUR POINTS TECHNOLOGY, LLC · PI Joel A Lipkin · 2018 to 2026
$255.6MSTRIDES OT2OD027060 · OD · CARAHSOFT TECHNOLOGY CORPORATION · PI Terry Drinkwine · 2018 to 2026
$134.1MHarmonized Data-Derived Resources for the Alzheimer's Disease and Related Dementias CommunityZIAAG000534 · NIA · NATIONAL INSTITUTE ON AGING · PI COOKSON, MARK · 2019 to 2025
$85.1MTDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2MNIH STRIDES - Azure and Associated Services and Training.OT2OD032100 · OD · DELL FEDERAL SYSTEMS L.P. · PI Amy K HammondOdwyer, Erum Siddiqui · 2021 to 2026
$62.2MProject 2: Biomarker Analysis, Non-Genetic Risk Factors, and Their Genetic InteractionsU19AG079774 · NIA · UNIVERSITY OF PENNSYLVANIA · PI HELENA Chang CHUI, Gyungah Jun · 2023 to 2026
$39.4MResearch Education ComponentP30AG062422 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Katherine P Rankin · 2019 to 2026
$36.9MTau Metabolism in FTD: From Gene Mutations to Molecular Chaperones and Lysosomal ProteasesU54NS123985 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI AGARD, DAVID A., KAO, AIMEE · 2021 to 2025
$9.0MAn automated machine learning approach to language changes in Alzheimer’s disease and frontotemporal dementia across Latino and English-speaking populationsR01AG075775 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI, Adolfo Martin Garcia · 2023 to 2026
$7.2MUS-South American Initiative for Genetic-Neural-Behavioral Interactions in Human Neurodegenerative ResearchR01AG057234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Claudia Duran-Aniotz, Agustin M. Ibanez · 2019 to 2026
$6.1MElucidating clinical heterogeneity in early-onset AD via genomics, transcriptomics, and neuroimagingR01AG062588 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI YOKOYAMA, JENNIFER S · 2019 to 2023
$4.0MCircadian Disturbance and Dementia in Latin AmericaR01AG083799 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI Kun Hu, Agustin M. Ibanez · 2023 to 2026
$3.0MIntramural NIH HHS ZIA AG000534NIA NIH HHS P01 AG019724NIA NIH HHS P30 AG062422NIA NIH HHS R01 AG057234NIA NIH HHS R01 AG062588NIA NIH HHS R01 AG075775NIA NIH HHS R01 AG083799NIA NIH HHS U19 AG079774NIDA NIH HHS 75N95022C00031NIH HHS OT2 OD027060NIH HHS OT2 OD027852NIH HHS OT2 OD032100NINDS NIH HHS U54 NS123985
Abstract
Latin America's diverse genetic landscape provides a unique opportunity to study Alzheimer's disease (AD) and frontotemporal dementia (FTD). The Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat) recruited 2162 participants with AD, FTD, or healthy controls from six countries: Argentina, Brazil, Chile, Colombia, Mexico, and Peru. Participants underwent genomic sequencing, and population structure analyses were conducted using Principal Component Analysis and ADMIXTURE. The study revealed a predominant mix of American, African, and European ancestries, with an additional East Asian component in Brazil. Variant curation identified 17 pathogenic variants, a pathogenic
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Cognitive ageingDementiaNeurodegenerative diseasesPopulation geneticsRare variants
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