ReviewFrontiers in nutrition2025
Edible evolution: the significance of food additives in shaping human health.
Review in Frontiers in nutrition, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Food additives with aldehyde skeleton exhibited leptin resistance in cells.Frontiers in nutrition · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Human diets have transitioned through distinct stages, from foraging to agriculture, domestication, and industrialization, that progressively altered food composition, availability, and ecological context. While these shifts enhanced food security and shelf life, they also narrowed dietary diversity and layered non-nutritive components ranging from salt and fermentation by-products to synthetic dyes, preservatives, artificial flavors, and non-caloric sweeteners onto ancestral nutritional frameworks. This review traces the historical integration of such compounds, situating them within broader dietary transitions to highlight how technological innovations gradually distanced human diets from their evolutionary origins. Drawing on nutritional anthropology, archaeogenomics, and ecological perspectives, we examine how these changes reshaped gut health, microbial diversity, and long-term disease risk. By framing non-nutritive additives within the long arc of dietary evolution, this perspective provides context for understanding the rise of modern, ultra-processed food systems and underscores the importance of integrating evolutionary and ecological evidence into contemporary nutrition and gastrointestinal research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.